Evaluating the levels of vitamins E, C, Malondialdehyde and some hematological parameters and gammaglutamyl transferase in patients with leukemia

Abstract EN

Leukemia is one of the most common cancer prevalent worldwide in both gender, and all races regardless of the level of living.

It affects blood-forming tissues especially the bone marrow.

Due to the importance of this disease and its risks, the study was carried out to evaluate the oxidative stress status and detect the effect of leukemia on some hematological parameters.

Estimate gamma glutamyle transferase (GGT).

A study was conducted between August 2016 till February 2017 in the center for Hematology/ Yarmouk Hospital.

The blood samples were collected from 70 Iraqi patients with leukemia and 37 normal persons as control group, their ages ranged from (6-68 years).

The statistical analysis of malondialdehyde (MDA) showed significant increase (P≤ 0.05) in patients with leukemia in compared to healthy.

While there was significant decrease in Vitamin C and E concentration in patients (7.10 ± 0.49; 8.75 ± 0.65 μmol/L respectively) in compared with healthy group (18.83 ± 0.67; 25.83 ± 0.88 μmol/L respectively).

The results of gamma glutamyle transferase (GGT) showed significant increase (P≤ 0.05) in patients with leukemia compared to healthy group.

The results of hematological parameters showed significant decrease (P≤ 0.05) in each of packed cell volume (PCV) in patients with leukemia compared to healthy group, and hemoglobin concentration in patients compared to healthy group, while there was a significant increase (P≤ 0.05) in total leukocytes count in patients with leukemia when compared to healthy group.

The results of the study showed a positive correlation between GGT and WBC.