DR D2 polymorphism in Egyptian with attention-deficit hyperactivity disorder children sample Marwa Mohamed Moro, Howida Hoseny El Gebaly, Eman Ahmed Zaky, Tarek Mostafa Kamal

Abstract EN

Background: ADHD is a highly heritable disorder.

Several genes were found to be involved; one of the commonest genes is dopamine D2 gene which was found to be associated with ADHD.

Objectives: The purpose of this study was the correlation of the children with ADHD DRD2 gene polymorphism.

We hypothesized a positive correlation of DRD2 polymorphisms in ADHD patients.

Methodology: Our research sample included 100 children aged between 4 and 12 years (8.1 ± 1.8).

The ADHD group consisted of 50 cases; diagnosed by Diagnostic and Statistical Manual of Mental Disorders, fourth Edition TR (DSM-IV-TR), and the 50 control of comparable age and sex.

PCR-RFLP analysis was done for the detection of the DRD2 polymorphism Results: A1 allele was more encountered in cases compared to controls, while the A2 allele was significantly more prevalent among controls.

A2 allele was statistically insignificant more encountered among mildly inattentive cases, and mild and moderate hyperactivity.

Conclusion: ADHD was significantly associated with dopamine D2 TaqI A Alleles polymorphism in the current study.