DR D2 polymorphism in Egyptian with attention-deficit hyperactivity disorder children sample Marwa Mohamed Moro, Howida Hoseny El Gebaly, Eman Ahmed Zaky, Tarek Mostafa Kamal
Source
Issue
Vol. 21, Issue 81 (31 Dec. 2018)10 p.
Publisher
Ain Shams University Faculty of Graduate Studies for Childhood
Publication Date
2018-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background: ADHD is a highly heritable disorder.
Several genes were found to be involved; one of the commonest genes is dopamine D2 gene which was found to be associated with ADHD.
Objectives: The purpose of this study was the correlation of the children with ADHD DRD2 gene polymorphism.
We hypothesized a positive correlation of DRD2 polymorphisms in ADHD patients.
Methodology: Our research sample included 100 children aged between 4 and 12 years (8.1 ± 1.8).
The ADHD group consisted of 50 cases; diagnosed by Diagnostic and Statistical Manual of Mental Disorders, fourth Edition TR (DSM-IV-TR), and the 50 control of comparable age and sex.
PCR-RFLP analysis was done for the detection of the DRD2 polymorphism Results: A1 allele was more encountered in cases compared to controls, while the A2 allele was significantly more prevalent among controls.
A2 allele was statistically insignificant more encountered among mildly inattentive cases, and mild and moderate hyperactivity.
Conclusion: ADHD was significantly associated with dopamine D2 TaqI A Alleles polymorphism in the current study.
American Psychological Association (APA)
Morrow, Marwah Muhammad& al-Jabali, Hwayda Husayni& Zaki, Iman Ahmad& Tariq Mustafa Kamal. 2018. DR D2 polymorphism in Egyptian with attention-deficit hyperactivity disorder children sample Marwa Mohamed Moro, Howida Hoseny El Gebaly, Eman Ahmed Zaky, Tarek Mostafa Kamal. Journal of Childhood Studies،Vol. 21, no. 81.
https://search.emarefa.net/detail/BIM-916960
Modern Language Association (MLA)
Morrow, Marwah Muhammad…[et al.]. DR D2 polymorphism in Egyptian with attention-deficit hyperactivity disorder children sample Marwa Mohamed Moro, Howida Hoseny El Gebaly, Eman Ahmed Zaky, Tarek Mostafa Kamal. Journal of Childhood Studies Vol. 21, no. 81 (Oct. / Dec. 2018).
https://search.emarefa.net/detail/BIM-916960
American Medical Association (AMA)
Morrow, Marwah Muhammad& al-Jabali, Hwayda Husayni& Zaki, Iman Ahmad& Tariq Mustafa Kamal. DR D2 polymorphism in Egyptian with attention-deficit hyperactivity disorder children sample Marwa Mohamed Moro, Howida Hoseny El Gebaly, Eman Ahmed Zaky, Tarek Mostafa Kamal. Journal of Childhood Studies. 2018. Vol. 21, no. 81.
https://search.emarefa.net/detail/BIM-916960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references.
Record ID
BIM-916960