Study of histopathological and biochemical effect of Punica granatum L. extract on streptozotocin-induced diabetes in rabbits
Other Title(s)
دراسة التأثيرات المرضية النسيجية و البايوكيميائية لمستخلص بذور الرمان على داء السكري المستحدث في الأرانب بواسطة عقار الستريبتوزوسين
Joint Authors
Sadiq, Ban Ismail
Sarhat, Intizar Rifat
Wadi, Siham Ajami
Jasim, Nawar Ali
Sarhat, Thurayya Rifat
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 33, Issue 2 (31 Dec. 2019), pp.189-194, 6 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
This study was undertaken to determine the antidiabetic effects of oral administration of Punica granatum L.
extract on serum and tissues of streptozotocin induced diabetic rabbits at 100 mg/kg.
The present study was carried out at the Faculty of veterinary Medicine, Tikrit University, from February to August 2017 for 10 weeks.
For this purpose, 30 rabbits were randomly separated into three groups, each containing 10 animals: Group 1, healthy control rabbits; Group 2, diabetic rabbits received streptozotocin (STZ, 65 mg/kg); Group 3, diabetic rabbits treated with PS extract (the 100 mg PS+1 ml DW) for 21 days.
At the end of experiment, blood samples were taken for measuring serum biochemical parameters.
For histopathological evaluation, sections of kidneys were fixed in 10% buffered formalin and 5micron thick sections with H&E stain were prepared using routine histopathological techniques.
The treatment revealed that PSE extract significant decreased serum glucose throm-bospondin-1, nitric oxide, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase alkaline phosphatase, and C-reactive protein in diabetic treated rabbits as compared to diabetic rabbits.
Histopathology of kidney showed lesions similar to human glomeruloscleroses, glomerular membrane thickening, arteriolar hyalinization and tubular necrosis.
From the above one can conclude that PSE extract possess nephroprotective effect in experimentally induced diabetic rabbits.
American Psychological Association (APA)
Sarhat, Intizar Rifat& Wadi, Siham Ajami& Sadiq, Ban Ismail& Sarhat, Thurayya Rifat& Jasim, Nawar Ali. 2019. Study of histopathological and biochemical effect of Punica granatum L. extract on streptozotocin-induced diabetes in rabbits. Iraqi Journal of Veterinary Sciences،Vol. 33, no. 2, pp.189-194.
https://search.emarefa.net/detail/BIM-917075
Modern Language Association (MLA)
Sarhat, Intizar Rifat…[et al.]. Study of histopathological and biochemical effect of Punica granatum L. extract on streptozotocin-induced diabetes in rabbits. Iraqi Journal of Veterinary Sciences Vol. 33, no. 2 (2019), pp.189-194.
https://search.emarefa.net/detail/BIM-917075
American Medical Association (AMA)
Sarhat, Intizar Rifat& Wadi, Siham Ajami& Sadiq, Ban Ismail& Sarhat, Thurayya Rifat& Jasim, Nawar Ali. Study of histopathological and biochemical effect of Punica granatum L. extract on streptozotocin-induced diabetes in rabbits. Iraqi Journal of Veterinary Sciences. 2019. Vol. 33, no. 2, pp.189-194.
https://search.emarefa.net/detail/BIM-917075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 193-194
Record ID
BIM-917075