Analgesic effect of silymarin in chicks

Abstract EN

There were no studies about the analgesic effect of silymarin in the chicken.

This study examined antinociceptive effect of silymarin given intraperitonially in 7-9 day-old chicks.

The median effective dose of silymarin for the induction of analgesia to electric stimulation in the chicks was 65.3 mg/kg.

Silymarin at 60, 120 and 240 mg/kg revealed analgesic effect to electric stimulation in chicks in dose dependent manner in comparison with the control group.

The analgesic effect of silymarin at 120 and 240 mg/kg started at 15 min after injection and lasted after over 120 min of injection were as silymarin at 60 mg/kg the analgesic effect started at 15 min after injection and declined before 120 min of injection.

The peak of analgesic effect for 60, 120 and 240 mg/kg were at 60 min after injection.

These results indicate that silymarin have an analgesic property in the chicks model