Serum lipoxin A4 decreases in exercise induced asthma

Abstract EN

Background: Lipoxin A4 is a potent anti- inflammatory and several lipoxin forming multicellular interactions occur during strenuous exercise Aim of the study: to evaluate diagnostic value of lipoxin A4 as a biomarker of exercise induced asthma Subfect& Methods: This cross sectional study was conducted on forty- five asthmatic children divided in two groups; EIA group: 25 children with history of exercise- induced symptoms of asthma confirmed by spirometry, Non EIA group: 20 patients who did no! have history of exercise induced symptoms of asthma.

Forty- five apparently healthy children were included as a control group with no history of asthma or atopic conditions.

Their age and sex were matched with the patients group.

For all patients, pulmonary function tests were done before and after a free running test using portable spiromometery.

Serum levels of lipoxin A4 were estimated for patients (after exercise) and controls using ELISA Results: A significant difference was detected between the levels of lipoxin A4 in EIA and contTo! groups (p value 0.000).

There was significant difference between Non EIA and control groups regarding the level of lipoxin A4 with (P valueO.OOO).

The mean level of lipoxin A4 in EIA patients was lower than that of Non EIA patients; however, the difference was statistically insignificant (P value 0.973).

Conclusion: lipoxin A4 is a promising anti- inflammaory factor in management of asthma.

It correlates with degree of reduction in FEV1 in EIA.

Future pharmaceutical studies should consider lipoxin as a new therapeutic treatment in EIA.