Screening for obesity in the offspring of first-cousin consanguineous couples : a phase-I study in Saudi Arabia

Joint Authors

Khan, Umran Ali
al-Harbi, Khalid Khalaf
al-Shaykh, Yazid A.
al-Sadi, Muslim M.
Mani, Balavenkatesh
Udayaraja, G. K.
Kahaylan, Muhammad

Source

Saudi Journal of Biological Sciences

Issue

Vol. 27, Issue 1 (31 Jan. 2020), pp.242-246, 5 p.

Publisher

Saudi Biological Society

Publication Date

2020-01-31

Country of Publication

Saudi Arabia

No. of Pages

5

Main Subjects

Biology

Topics

Abstract EN

Consanguineous or cousin marriages are very common in Saudi Arabia.

However, owing to limited studies and insufficient knowledge about genetic diseases/disorders, many couples are unaware of the increased health risks for their offspring.

Among the inherited and complex diseases from parents’ consanguinity, obesity is common; therefore, we examined the prevalence of obesity in the offspring of first-cousin consanguineous couples in Saudi Arabia.

In this questionnaire-based study, 657 individuals (mean age = 18.7 ± 10.2 years; age range = 2–65 years) who were residing in Riyadh, Saudi Arabia participated.

Among them, almost 90% were native Saudis.

Participants mean body mass index (BMI) was 24.5 ± 9.1 kg/m2.

Sex- stratified demographic details confirmed a significant association between age and BMI (p < .001).

We confirmed that adolescents and adults were more prone to develop obesity.

Adults and non-Saudi participants were three times more likely to develop obesity if they had first-cousin consanguineous parents than those who did not.

Of the 30% of participants who were obese, 100 will be selected for Phase II, in which we plan to perform exome sequencing.

American Psychological Association (APA)

al-Harbi, Khalid Khalaf& al-Shaykh, Yazid A.& al-Sadi, Muslim M.& Mani, Balavenkatesh& Udayaraja, G. K.& Kahaylan, Muhammad…[et al.]. 2020. Screening for obesity in the offspring of first-cousin consanguineous couples : a phase-I study in Saudi Arabia. Saudi Journal of Biological Sciences،Vol. 27, no. 1, pp.242-246.
https://search.emarefa.net/detail/BIM-920583

Modern Language Association (MLA)

al-Harbi, Khalid Khalaf…[et al.]. Screening for obesity in the offspring of first-cousin consanguineous couples : a phase-I study in Saudi Arabia. Saudi Journal of Biological Sciences Vol. 27, no. 1 (Jan. 2020), pp.242-246.
https://search.emarefa.net/detail/BIM-920583

American Medical Association (AMA)

al-Harbi, Khalid Khalaf& al-Shaykh, Yazid A.& al-Sadi, Muslim M.& Mani, Balavenkatesh& Udayaraja, G. K.& Kahaylan, Muhammad…[et al.]. Screening for obesity in the offspring of first-cousin consanguineous couples : a phase-I study in Saudi Arabia. Saudi Journal of Biological Sciences. 2020. Vol. 27, no. 1, pp.242-246.
https://search.emarefa.net/detail/BIM-920583

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 245-246

Record ID

BIM-920583