The down regulation of PTP1B expression and attenuation of disturbed glucose and lipid metabolism using Borassus flabellifer (L) fruit methanol extract in high fat diet and streptozotocin induced diabetic rats
Joint Authors
Ismail, Jalal Ali
William Raja, T.
Ganesan, P.
Ahilan, B.
Valan Arasu, M.
Balamurugan, R.
Ignacimuthu, S.
Duraipandiyan, V.
al-Dhabi, Nayif Abd Allah
Source
Saudi Journal of Biological Sciences
Issue
Vol. 27, Issue 1 (31 Jan. 2020), pp.433-440, 8 p.
Publisher
Publication Date
2020-01-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Borassus flabellifer L.
is a tall palm traditionally used for its stimulating, diuretic and anti-inflammatory activities; it is rich in fibers and various pharmacologically important secondary metabolites.
This study was undertaken to evaluate the antidiabetic effects of Borassus flabellifer fruit methanol extract (BF-M) on diabetic rats induced with High Fat Diet (HFD)/streptozotocin (STZ).
When BF-M (100 or 200 mg/kg) was administered for 21 days orally it led to a sharp decline in triglycerides, total cholesterol, free unsaturated fat, glucose-6-phosphate, fasting blood glucose and fructose 1,6 bisphosphatase in contrast to diabetic control.
BF-M also downregulated Protein Tyrosine Phosphatase 1B.
In vitro study showed the IC50 value to be 23.98 μg/mL.
BF-M significantly increased serum insulin, glycogen content, and body weight.
Western blot analysis exhibited significant inhibition of PTP1B in pancreatic tissue which was confirmed by histology and immunohistological studies.
GC-MS analysis revelaled that the presence of major compounds such as 5-hydroxymethylfurfural (47.56%), Guanosine (21.01%) and n-hecxadeconoic acid (25.14%) in BF-M.
In short, BF-M exerted antidiabetic property by down regulating PTP1B expression, and eventually enhancing glucose stimulated insulin release; it also exhibited favorable effects in diabetes and its secondary complications.
American Psychological Association (APA)
Duraipandiyan, V.& Balamurugan, R.& al-Dhabi, Nayif Abd Allah& William Raja, T.& Ganesan, P.& Ahilan, B.…[et al.]. 2020. The down regulation of PTP1B expression and attenuation of disturbed glucose and lipid metabolism using Borassus flabellifer (L) fruit methanol extract in high fat diet and streptozotocin induced diabetic rats. Saudi Journal of Biological Sciences،Vol. 27, no. 1, pp.433-440.
https://search.emarefa.net/detail/BIM-920709
Modern Language Association (MLA)
Duraipandiyan, V.…[et al.]. The down regulation of PTP1B expression and attenuation of disturbed glucose and lipid metabolism using Borassus flabellifer (L) fruit methanol extract in high fat diet and streptozotocin induced diabetic rats. Saudi Journal of Biological Sciences Vol. 27, no. 1 (Jan. 2020), pp.433-440.
https://search.emarefa.net/detail/BIM-920709
American Medical Association (AMA)
Duraipandiyan, V.& Balamurugan, R.& al-Dhabi, Nayif Abd Allah& William Raja, T.& Ganesan, P.& Ahilan, B.…[et al.]. The down regulation of PTP1B expression and attenuation of disturbed glucose and lipid metabolism using Borassus flabellifer (L) fruit methanol extract in high fat diet and streptozotocin induced diabetic rats. Saudi Journal of Biological Sciences. 2020. Vol. 27, no. 1, pp.433-440.
https://search.emarefa.net/detail/BIM-920709
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 439-440
Record ID
BIM-920709