Determination of doxycycline hyclate in pharmaceutical samples via oxidative coupling reaction using spectrophotometric method
Other Title(s)
تقدير الدوكسي سايكلين هيكلات في العينات الصيدلانية عن طريق تفاعل الاقتران التاكسدي باستخدام طريقة طيفية
Author
Source
Journal of University of Anbar for Pure Science
Issue
Vol. 12, Issue 2 (31 Aug. 2018), pp.29-36, 8 p.
Publisher
University of Anbar College of Science
Publication Date
2018-08-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
This study involves the development of spectrophotometric method for determination of microgram a suggested mounts of doxycycline Hyclate (DCH) via oxidative coupling with 2,4,dinitrophenylhydrazine reagent (2,4-DNPH) in presence of potassium periodate(KIO4) in the alkaline medium (pH 12.6) to form a red colored dye which soluble in water and gives the highest intensity of absorption at λmax 528 nm.
The method has been obeyed Beer's law in the concentration range 5-60 μg.ml-1with the molar absorptivity of 10771 L.
mol-1.
cm-1, sandel index value 0.0476 μg.cm-2 with the relative standard deviation of the method does not exceed its value 1.043 % and the correlation coefficient 0.998.
the proposed method was applied successfully for the determination of doxycycline hyclate in its pharmaceutical samples (Capsule).
American Psychological Association (APA)
Hamidi, Isra Talib. 2018. Determination of doxycycline hyclate in pharmaceutical samples via oxidative coupling reaction using spectrophotometric method. Journal of University of Anbar for Pure Science،Vol. 12, no. 2, pp.29-36.
https://search.emarefa.net/detail/BIM-920828
Modern Language Association (MLA)
Hamidi, Isra Talib. Determination of doxycycline hyclate in pharmaceutical samples via oxidative coupling reaction using spectrophotometric method. Journal of University of Anbar for Pure Science Vol. 12, no. 2 (2018), pp.29-36.
https://search.emarefa.net/detail/BIM-920828
American Medical Association (AMA)
Hamidi, Isra Talib. Determination of doxycycline hyclate in pharmaceutical samples via oxidative coupling reaction using spectrophotometric method. Journal of University of Anbar for Pure Science. 2018. Vol. 12, no. 2, pp.29-36.
https://search.emarefa.net/detail/BIM-920828
Data Type
Journal Articles
Language
English
Record ID
BIM-920828