Evaluating some biochemical parameters after repeated orally administration of levofloxacin in male rats
Other Title(s)
تقييم بعض العوامل الكيموحياتية بعد التجريع المتكرر لعقار الليفوفلوكساسين في ذكور الجرذان المهقاء
Joint Authors
al-Sufi, Wail Futuh
al-Rikabi, Falah Musa Kazim
Source
Journal of Biotechnology Research Center
Issue
Vol. 12, Issue 2 (31 Dec. 2018), pp.51-60, 10 p.
Publisher
al-Nahrain University Biotechnology Research Center
Publication Date
2018-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
This study was conducted to evaluate some biochemical parameters of levofloxacin in male rats.
It was carried out on fifty four of the albino male rats, they were divided into three main groups equally and orally dosed levofloxacin and assigned as, the first group was dosed with the therapeutic dose 7.5mg/kg/bw, the second group was dosed with the double therapeutic dose 15mg/kg/bw, the third group was dosed with distilled water (negative control).
The three groups were divided into three subgroups equally according to dosing period of 2 weeks, 4 weeks, 1 week after discontinuation of dosing.
The results showed, there were significant P<0.05 increases in creatine kinase myocardial band of group 1 after 4 weeks of treatment and 1 week of levofloxacin withdrawal in comparison with control group, also there were significant P<0.05 increases in troponin-t of group 2 after 1 week of levofloxacin withdrawal in comparison with control group.
While aspartate aminotransferase, total plasma protein, and creatinine levels showed significant P<0.05 increases and significant P<0.05 decreases in total plasma bilirubin level, but within normal limits, between experimental groups and control group.
Whereas, there were no significant P>0.05 changes in blood urea nitrogen levels between the experimental groups.
We concluded that levofloxacin revealed minor toxic effects on organs tissue and most of these effects were reversible.
American Psychological Association (APA)
al-Sufi, Wail Futuh& al-Rikabi, Falah Musa Kazim. 2018. Evaluating some biochemical parameters after repeated orally administration of levofloxacin in male rats. Journal of Biotechnology Research Center،Vol. 12, no. 2, pp.51-60.
https://search.emarefa.net/detail/BIM-920980
Modern Language Association (MLA)
al-Sufi, Wail Futuh& al-Rikabi, Falah Musa Kazim. Evaluating some biochemical parameters after repeated orally administration of levofloxacin in male rats. Journal of Biotechnology Research Center Vol. 12, no. 2 (2018), pp.51-60.
https://search.emarefa.net/detail/BIM-920980
American Medical Association (AMA)
al-Sufi, Wail Futuh& al-Rikabi, Falah Musa Kazim. Evaluating some biochemical parameters after repeated orally administration of levofloxacin in male rats. Journal of Biotechnology Research Center. 2018. Vol. 12, no. 2, pp.51-60.
https://search.emarefa.net/detail/BIM-920980
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-920980