Polymorphism of P-selectin (- 2123CG, rs1800807 CG)‎ and IL-4 -1098 in a sample of Iraqi diabetes mellitus type 2

Abstract EN

Diabetes is a major public health problem because it is world’s sixth cause of death.

An inflammatory disease that associated with many inflammatory markers, which is a key for complications of vascular endothelial system, literally for high risk populations.

Some adhesion molecules were studied in the sera of Iraqi Arab female as P-selectin associated with inflammatory disease and Cytokines.

This work tend to evaluate the association between soluble P-selectin level, polymorphism for mutation site 2123C/G (rs1800807) and the role of P-selectin and IL-4 polymorphism in the developing of Diabetes Mellitus type 2.

Genetic polymorphism of P-selectin gene was investigated at the position -2123C/G, Present study illustrated three genotypes (GG, GC, CC), with the significant protective effect for G allele and Etiological effect for C allele.

The Polymorphism of IL-4- gene at the position IL-4 -1098 was presented with three genotypes (TT, TC and CC), Furthermore the result of C allele frequency (RR=1.45 with EF=0.312) reflect an Etiological effect for C allele with positive association with disease.

All present factors in the first view may occur as independent risk factors but after a deeply focusing on results, it seems as if there’s a sequence functions among them, the result in a synergist effect interfere with Diabetes Mellitus type 2