Role of the anesthetic determine the clonidine effects mediated by RVLM -α2-adrenoceptors on blood pressure and heart rate in rats
Other Title(s)
دور نوع المخدر في تاثيرات الكلوندين المعتمدة على مستقبلات ألفا -2- الادرينيرجيكية منطقة RVLM على ضغط الدم و دقات القلب في الجرذان
Author
Source
Journal of Biotechnology Research Center
Issue
Vol. 12, Issue 1 (30 Jun. 2018), pp.64-78, 15 p.
Publisher
al-Nahrain University Biotechnology Research Center
Publication Date
2018-06-30
Country of Publication
Iraq
No. of Pages
15
Main Subjects
Abstract EN
To examine the hypothesis of a role for α2-adrenoceptors in mediating the mechanism of urethane hypotensive effect whether it's peripheral or central, Wistar rats were anesthetized with urethane or (for comparison) with halothane, to study the influence of urethane that govern the mechanism of central and peripheral α2-adrenoceptors action, on basal BP & HR, and the rise in blood pressure (BP) to the stimulation of caudal pressor area (CPA), when these receptors were either centrally activated by bilateral rostral ventrolateral medulla (RVLM) microinjection of clonidine (30nM), and blockade with any of the clonidine antagonists, yohimbine (500pmol/50nl), and idazoxane (270nM) or yohimbine+idazoxane, or when peripherally activated (of urethane anesthetized rats) by i.v.
clonidine (100nmol/kg), which also blockade with idazoxane or yohimbine+idazoxane.
The results indicated presence of no anesthetic differences in a partial involvement of α2-receptors-RVLM, vs.
a complete involvement of I(1)-imidazole receptors in mediating the hypotensive effects of clonidine.
It also indicates α2-/I(1)-receptors synergism in raising the urethane lowering of baseline of SBP to the levels of control or halothane group.
In conclusion, the result suggests involvement both of the central and the peripheral α2-adrenoceptors in mediating urethane hypotensive effects.
American Psychological Association (APA)
Rashid, Imad Hatim. 2018. Role of the anesthetic determine the clonidine effects mediated by RVLM -α2-adrenoceptors on blood pressure and heart rate in rats. Journal of Biotechnology Research Center،Vol. 12, no. 1, pp.64-78.
https://search.emarefa.net/detail/BIM-921331
Modern Language Association (MLA)
Rashid, Imad Hatim. Role of the anesthetic determine the clonidine effects mediated by RVLM -α2-adrenoceptors on blood pressure and heart rate in rats. Journal of Biotechnology Research Center Vol. 12, no. 1 (2018), pp.64-78.
https://search.emarefa.net/detail/BIM-921331
American Medical Association (AMA)
Rashid, Imad Hatim. Role of the anesthetic determine the clonidine effects mediated by RVLM -α2-adrenoceptors on blood pressure and heart rate in rats. Journal of Biotechnology Research Center. 2018. Vol. 12, no. 1, pp.64-78.
https://search.emarefa.net/detail/BIM-921331
Data Type
Journal Articles
Language
English
Record ID
BIM-921331