A clinical study on the expression of miR-195 in cardiac carcinoma

Joint Authors

Wang, Hao
Ba, Cai Xia
Bai, Xue Feng
Zhang, Pei Long
Zhang, Gang Ling
Tian, Bing Chang
Li, Zuo Jun
Zhou, Shui Ying
Yu, Fei

Source

Iranian Red Crescent Medical Journal

Issue

Vol. 22, Issue 1 (31 Jan. 2020), pp.1-6, 6 p.

Publisher

Iranian Hospital

Publication Date

2020-01-31

Country of Publication

United Arab Emirates

No. of Pages

6

Main Topic

Medicine

Topics

Abstract EN

Background: Recently, some studies have revealed that microRNAs (miRs; miRNAs) mainly regulate gene expression in the transcription of microRNAs.

However, the role of microRNAs in cell development, differentiation, proliferation, and other physiological processes remains unclear.

Objectives: The present study aimed to investigate the expression level of microRNA-195 in the pathological tissues of patients with cardiac carcinoma and its clinical effects.

Methods: Patients with primary cardiac carcinoma were enrolled as the study subjects.

The tumor and adjacent tissue samples for cancer pathology were obtained during the operation.

Reverse transcription polymerase chain reaction (RT-PCR) was used to detect the expression of microRNA-195 and its correlation with the clinicopathological features of cardiac carcinoma was analyzed.

Results: A total of 64 patients were included in this study.

Firstly, the expression rate of miR-195 in cardiac carcinoma tissues showed a significant decreasing trend (3.65 ± 0.42 vs.

2.05 ± 0.33) (P < 0.001) and the actual expression level of miR-195 in pathological tissues of cardiac carcinoma was negatively correlated with the malignant degree of pathological tissues (P = 0.028), invasion (P = 0.037), and lymph node metastasis of cardiac carcinoma (P = 0.023), but miR-195 was not correlated with age (P = 0.615) and gender (P = 0.465).

Conclusions: The expression of microRNA-195 is closely correlated to the severity of cardiac carcinoma and the occurrence of lymph node metastasis.

American Psychological Association (APA)

Wang, Hao& Ba, Cai Xia& Bai, Xue Feng& Zhang, Pei Long& Zhang, Gang Ling& Yu, Fei…[et al.]. 2020. A clinical study on the expression of miR-195 in cardiac carcinoma. Iranian Red Crescent Medical Journal،Vol. 22, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-932907

Modern Language Association (MLA)

Yu, Fei…[et al.]. A clinical study on the expression of miR-195 in cardiac carcinoma. Iranian Red Crescent Medical Journal Vol. 22, no. 1 (Jan. 2020), pp.1-6.
https://search.emarefa.net/detail/BIM-932907

American Medical Association (AMA)

Wang, Hao& Ba, Cai Xia& Bai, Xue Feng& Zhang, Pei Long& Zhang, Gang Ling& Yu, Fei…[et al.]. A clinical study on the expression of miR-195 in cardiac carcinoma. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 1, pp.1-6.
https://search.emarefa.net/detail/BIM-932907

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 5-6

Record ID

BIM-932907