Synthesis, cytotoxicity, xanthine oxidase inhibition, antioxidant of new pyrazolo {3,4 d} pyrimidine derivatives
Other Title(s)
تحضير مشتقات جديدة لمركب بايروزولو (3,4,d) بايريمدن و قياس سميتها و قابليتها على تثبيط أنزيم الزانثين أوكسيديز و فعاليتها كعوامل مؤكسدة
Joint Authors
Hammud, Ahlam Jamil
al-Bayati, Samiah Jumah Khammas
Source
Issue
Vol. 16, Issue 4 (sup) (31 Dec. 2019), pp.1003-1009, 7 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Allopurinol derivative were prepared by reacting the (1-chloroacetyl)-2-Hydropyrazolo{3,4-d}pyrimidine-4-oneiwith 5- methoxy- 2-aminoibenzothiazoleiunder certain conditions to obtain new compound ( N- (2-aminoacetyl (5-methoxy) benzothiazole -2yl) (A4), Reaction of 5-(P-dimethyl amine benzene)-2-amino-1,3,4- oxadiazole in the presence of potassium carbonate anhydrous to yield new compound (N-(2- aminoacetyl-5-(P-dimethyl amine benzene )-1,3,4-oxadiazoles-2-yl)(A30) and Azo compound (N-(5-(Azo-2-hydroxy-5-amino benzene)-1,3-Diazol-2yl)Allopurinol(A46).
The structure of prepared compounds were confirmed by (FT-IR) technique and their physical properties.
The synthesized compounds were tested for cytotoxicity, Xanthine oxidase inhibition, and antioxidant activity.
American Psychological Association (APA)
al-Bayati, Samiah Jumah Khammas& Hammud, Ahlam Jamil. 2019. Synthesis, cytotoxicity, xanthine oxidase inhibition, antioxidant of new pyrazolo {3,4 d} pyrimidine derivatives. Baghdad Science Journal،Vol. 16, no. 4 (sup), pp.1003-1009.
https://search.emarefa.net/detail/BIM-935371
Modern Language Association (MLA)
al-Bayati, Samiah Jumah Khammas& Hammud, Ahlam Jamil. Synthesis, cytotoxicity, xanthine oxidase inhibition, antioxidant of new pyrazolo {3,4 d} pyrimidine derivatives. Baghdad Science Journal Vol. 16, no. 4 (Supplement) (2019), pp.1003-1009.
https://search.emarefa.net/detail/BIM-935371
American Medical Association (AMA)
al-Bayati, Samiah Jumah Khammas& Hammud, Ahlam Jamil. Synthesis, cytotoxicity, xanthine oxidase inhibition, antioxidant of new pyrazolo {3,4 d} pyrimidine derivatives. Baghdad Science Journal. 2019. Vol. 16, no. 4 (sup), pp.1003-1009.
https://search.emarefa.net/detail/BIM-935371
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in English and Arabic.
Record ID
BIM-935371