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Spectrophotometric determination of mesalazine in pharmaceutical preparations by oxidative coupling reactions with m-aminophenol and 2,6-dihydroxybenzoic acid
Other Title(s)
التقدير الطيفي للميزالازين في المستحضرات الصيدلانية بوساطة تفاعلات الاقتران التأكسدي مع ميتا-امينوفينول و ،2 6-ثنائي هيدروكسي حامض البنزويك
Joint Authors
Aziz, Ala Taha
Sultan, Sad Hassani
Source
Issue
Vol. 16, Issue 4 (sup) (31 Dec. 2019), pp.1010-1016, 7 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Abstract EN
Tow simple, rapid and sensitive spectrophotometric methods for the determination of mesalazine in pharmaceutical preparations have been carried out.
The proposed methods depend on oxidative coupling reaction of mesalazine with m-aminophenol in the existence of N-bromosuccinamide in alkaline medium (method A) and 2,6-dihydroxybenzoic acid in the existence of sodium metaperiodate in basic medium (method B) to produce colored products , show highest absorptions at 640 (nm) and 515 (nm), alternately.
Beer’s law was consistent in concentrations extent of 1.25-30 and 0.5-12.5 (μg.mL-1) with molar absorptivity of 0.36×104 and 0.77×104 L.mol-1.cm-1, alternately.
The limits of detection (LOD) were 0.0144 and 0.0829 μg.mL-1, while limits of quantitation (LOQ) were 0.0483 and 0.2766 (μg.mL-1), alternately.
The suggested methods have been applied successfully to the determination of mesalazine in its pharmaceutical preparations as tablets and suppositories.
American Psychological Association (APA)
Aziz, Ala Taha& Sultan, Sad Hassani. 2019. Spectrophotometric determination of mesalazine in pharmaceutical preparations by oxidative coupling reactions with m-aminophenol and 2,6-dihydroxybenzoic acid. Baghdad Science Journal،Vol. 16, no. 4 (sup), pp.1010-1016.
https://search.emarefa.net/detail/BIM-935377
Modern Language Association (MLA)
Aziz, Ala Taha& Sultan, Sad Hassani. Spectrophotometric determination of mesalazine in pharmaceutical preparations by oxidative coupling reactions with m-aminophenol and 2,6-dihydroxybenzoic acid. Baghdad Science Journal Vol. 16, no. 4 (Supplement) (2019), pp.1010-1016.
https://search.emarefa.net/detail/BIM-935377
American Medical Association (AMA)
Aziz, Ala Taha& Sultan, Sad Hassani. Spectrophotometric determination of mesalazine in pharmaceutical preparations by oxidative coupling reactions with m-aminophenol and 2,6-dihydroxybenzoic acid. Baghdad Science Journal. 2019. Vol. 16, no. 4 (sup), pp.1010-1016.
https://search.emarefa.net/detail/BIM-935377
Data Type
Journal Articles
Language
English
Notes
Text in English ; abstracts in English and Arabic.
Record ID
BIM-935377