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Glycine improves peritoneal vasoreactivity to dialysis solutions in the elderly
Joint Authors
Zakariyya, al-Rashid
Juzif, Bilal
al-Jamal, Abd al-Rahman
Sartaj, Fahim
al-Thani, Maha
Fadl, Tasnim
Madan, Dana
Hamidi, Muhammad A. M.
Zeeshan, Muhammad
Source
Issue
Vol. 2019, Issue 3 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Qatar
No. of Pages
14
Main Subjects
Abstract EN
Background: Peritoneal dialysis solution (PDS) dilates peritoneal microvessels predominantly by the activation of the endothelial nitric oxide (NO) pathway.
We made an incidental observation of decreased PDS-induced, NO-dependent peritoneal microvascular vasoreactivity in elderly rats naïve to PDS exposure.
We hypothesized that this subordinate NO-mediated peritoneal microvascular vasoreactivity is caused by increased oxidative stress in the aged endothelium, which compromises NO bioavailability in the elderly, and that peritoneal microvascular vasoreactivity can be improved by the supplementation of antioxidant glycine to PDS.
Methods:We studied PDS-mediated vasoreactivity of four intestinal visceral arterioles of different orders by in vivo intravital microscopy in weaned, adult, and elderly rats to (i) confirm subordinate vasoreactivity to PDS in elderly rats; (ii) restore vasoreactivity by glycine supplementation; and (iii) establish age as an independent risk factor for endothelial cell dysfunction.
Results: In a crossover series, peritoneal microvascular vasoreactivity to PDS exposure was remarkably decreased in elderly rats.
This subordinate vasoreactivity was completely restored by the supplementation of glycine to PDS.
In a separate series, we assessed in situ endothelial cell function in weaned and adult rats using the cumulative acetylcholine concentration–response curves.
Unlike the adults, the weaned rats demonstrated remarkable sensitivity and reactivity to cumulative acetylcholine concentrations, suggesting the dependency of endothelial cell function on age.
Conclusion: Aging is an independent risk factor for peritoneal microvascular endothelial cell dysfunction.
Endothelial function in the elderly can be recovered by reinforcing the bioavailability of endothelial-derived NO through glycine.
Dietary glycine supplementation is a potential therapeutic strategy to decrease the burden of oxidative stress on the aged endothelium.
American Psychological Association (APA)
Zakariyya, al-Rashid& Juzif, Bilal& Hamidi, Muhammad A. M.& Zeeshan, Muhammad& al-Jamal, Abd al-Rahman& Sartaj, Fahim…[et al.]. 2019. Glycine improves peritoneal vasoreactivity to dialysis solutions in the elderly. Qatar Medical Journal،Vol. 2019, no. 3, pp.1-14.
https://search.emarefa.net/detail/BIM-935467
Modern Language Association (MLA)
Zakariyya, al-Rashid…[et al.]. Glycine improves peritoneal vasoreactivity to dialysis solutions in the elderly. Qatar Medical Journal No. 3 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-935467
American Medical Association (AMA)
Zakariyya, al-Rashid& Juzif, Bilal& Hamidi, Muhammad A. M.& Zeeshan, Muhammad& al-Jamal, Abd al-Rahman& Sartaj, Fahim…[et al.]. Glycine improves peritoneal vasoreactivity to dialysis solutions in the elderly. Qatar Medical Journal. 2019. Vol. 2019, no. 3, pp.1-14.
https://search.emarefa.net/detail/BIM-935467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 13-14
Record ID
BIM-935467