Assessment of the serum level of melatonin and its correlation with insulin, insulin resistance, and glycated hemoglobin in Iraqi patients with polycystic ovarian syndrome

Abstract EN

Background: Polycystic ovarian syndrome (PCOS) is one of the most frequent gynecological endocrinopathy that occur in premenopausal females.

The importance of melatonin (N‑acetyl‑5‑methoxytryptamine) in human reproduction is still unidentified.

A numerous study suggests that melatonin and reproductive hormones are closely related.

Objectives: The study aimed to evaluate the role of melatonin in women with PCOS and its correlation with insulin, insulin resistance (IR), and glycated hemoglobin (HbA1c) in a patient with PCOS.

Materials and Methods: A prospective cross‑sectional study was designed taking 60 PCOS patients and 30 controls women from January to April 2019.

These patients admitted to obstetrics and gynecology unit at Babylon teaching hospital.

Five milliliter of blood sample was taken on day 2 of menstrual cycle from each subject enrolled in this study.

Blood samples were collected for testing serum melatonin, insulin, IR, and HbA1c estimation.

Results: The study showed that there is the significant difference between PCOS women and the control group concerning melatonin level.

Results also showed higher means of HbA1c in PCOS women than control women, and positive correlation between HbA1c and melatonin.

The study showed higher means of insulin was shown in PCOS women when compared with control group, and positive correlation between insulin and melatonin.

Furthermore, this study showed higher means of IR was recorded in PCOS women when compared with control group, and positive correlation between IR and melatonin.

Conclusions: Women with PCOS have significant increase of serum melatonin in PCOS women.

And, there were significant increases in serum levels of HbA1c, insulin, and IR in women with PCOS compared to healthy women.

In addition, positive correlation was found between melatonin with insulin, IR, and HbA1c.

This study could open the way for therapeutic role of melatonin in the treatment of PCOS women.