Synthesis and biological investigation of novel adamantylated heterocyclic rings with chalcone based structure

Abstract EN

In this study, we have synthesized four different adamantylated heterocyclic compounds (pyrimidine, pyran (I), pyran (II), and pyridine) and characterized by using Proton Nuclear Magnetic Resonance (1H-NMR), Fourier Transform Infrared (FT-IR) and Ultraviolet–visible (UV-Vis) spectroscopy.

Thin Layer Chromatography (TLC) and melting point measurements were elucidated for chalcone, pyrimidine, pyran and pyridine.

The synthesized compounds were investigated against human breast adenocarcinoma cell line (MCF-7).

The cells were treated in a dose-dependent manner (0, 4, 16, 32, 64, 128 and 256 μg/ml) for 24 hours as an incubation time using MTT viability assay 3-(4,5-dimethyl-2-thiazol)-2,5-diphenyl-2H-tetrazolium bromide).

Pyran (I) and pyran (II) are synthesized in different reaction conditions.

The results show that pyrimidine, pyran (I), and pyridine have cytotoxicity effects against MCF-7 cell line at concentration 64-256 μg/ml.

However, pyran (II) shows little effect on MCF-7 cell line at 128μg/mL.