Toxicological and histopathological effects of Diazinon and sodium benzoate on the nile tilapia fish, Oreochromis niloticus L.

Abstract EN

The acute and subchronic toxicity of diazinon and sodium benzoate to the Nile tilapia fish, Oreochromis niloticus L.

٦٠ g weight were studied.

The obtained results showed that the LC٥٠ after ٢٤, ٤٨, ٧٢ and ٩٦ hr., post treatment to the insecticide diazinon were ٨.٣٧٧, ٦.٨٥٢, ٦.٢٠٠ and ٥.٦٧٩ mg/l, respectively.

Exposed fish to sublethal concentration of diazinon (٠.٥٦ mg/l) and sodium benzoate at ١٥٠ mg/l for ٢١days caused some biochemical and histopathological changes in some blood components and organs.

Diazinon increased alanine amino transferase (ALT), aspartate amino transferase (AST), glucose, total protein, albumin, creatinine and cholesterol activities, while acetylcholinesterase (AchE) and uric acid were decreased.

Sodium benzoate caused an increase of ALT, AST, glucose, total protein, albumin, creatinine, uric acid and cholesterol activities.

The histopathological studies showed degeneration of hepatocytes, congestion of blood vessels and revealed degenerative changes on some organs and cystic dilatation of some renal tubules together with congestion of renal blood vessels and mild to moderate lymphocytic infiltration were detected compared with control fish (untreated).