Recent isoniazid derivatives as anti-tubercular agents : review article
Other Title(s)
المشتقات الحديثة للأيزونيازيد كعامل مضاد للسل : دراسة مرجعية
Joint Authors
al-Ali, Muhannad
Bawadiqji, Abd al-Hakim
Source
Journal of the North for Basic and Applied Sciences
Issue
Vol. 4, Issue 2 (30 Nov. 2019), pp.139-158, 20 p.
Publisher
Northern Border University Scientific Publishing Center
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
20
Main Subjects
Topics
Abstract EN
Tuberculosis (TB) remains a global pandemic.
Isoniazid (INH) is an extensively studied antiTB medicine.
However, the recently emerged MDR and TDR TBs have posed challenges to the scientific community to produce more effective anti-TB agents possessing potent effects on the two strains of TB, lesser toxicity and drug interactions with current drugs, reduce the duration of therapy, and have a new mechanism of action to avoid recurrence of MDR.
Accordingly, based on the abnormal lipophilic character of the cell wall of M.
tuberculosis, novel lipophilic isoniazid derivatives have been prepared as hybrids of pyrrole, pyrazole, pyrazoline, triazole, triazine, azetidinone, quinoline, quinolone, thiazolidinone, isatin, cinnamic acid, furoxan, and Schiff bases of certain aldehydes and ketone.
This strategy has resulted in the development of some promising INH hybrids as anti-TB agents, for example, LL-3858 that progressed to the advanced stage of phase II clinical trial.
This review provides a summary of the novel INH-hybrids/ derivatives as anti-TB agents.
It is expected that safer and effective drugs, including these INH-hybrids/ derivatives, may be approved in the future by drug regulatory authorities globally.
American Psychological Association (APA)
Imran, Mohd.& Bawadiqji, Abd al-Hakim& al-Ali, Muhannad. 2019. Recent isoniazid derivatives as anti-tubercular agents : review article. Journal of the North for Basic and Applied Sciences،Vol. 4, no. 2, pp.139-158.
https://search.emarefa.net/detail/BIM-938550
Modern Language Association (MLA)
Imran, Mohd.…[et al.]. Recent isoniazid derivatives as anti-tubercular agents : review article. Journal of the North for Basic and Applied Sciences Vol. 4, no. 2 (Nov. 2019), pp.139-158.
https://search.emarefa.net/detail/BIM-938550
American Medical Association (AMA)
Imran, Mohd.& Bawadiqji, Abd al-Hakim& al-Ali, Muhannad. Recent isoniazid derivatives as anti-tubercular agents : review article. Journal of the North for Basic and Applied Sciences. 2019. Vol. 4, no. 2, pp.139-158.
https://search.emarefa.net/detail/BIM-938550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 154-158
Record ID
BIM-938550