Effect of nigella sativa oil on the imidacloprid induced toxicity in male albino mice
Other Title(s)
تأثير زيت حبة البركة Nigella sativa على السمية المستحثة بمبيد الايميداكلوبريد في ذكور الفئران الببيضاء
Author
Ali, Rida Khamis Abd al-Razzaq
Source
Alexandria Journal of Agricultural Sciences
Issue
Vol. 63, Issue 4 (31 Aug. 2018), pp.239-250, 12 p.
Publisher
Alexandria University Faculty of Agriculture
Publication Date
2018-08-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Imidacloprid (IMC) is a systemic insecticide being the most frequently detected neonicotinoid in fruits and vegetables.
So, this study was carried out to evaluate the biochemical and the histological alterations associated with IMC toxicity in male albino mice (Muss musculus).
Also, the role of Nigella Sativa oil (NS oil), (4 ml/kg bw) on the adverse effect of IMC was investigated.
The animals were orally administered with 1/50 LD50 IMC (2.6 mg/kg bw) for 28 days (5 doses/week).
Hepatic and pancreatic toxicity was monitored by quantitative measurements of the serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), α- amylase activities, glucose, total cholesterol, triglyceride, and high-density lipoprotein (HDL) cholesterol levels.
Creatinine and urea levels were used as the biomarkers of kidney damages.
The results showed that imidacloprid administration caused a significant increase in the body and the organs weights.
Also, the ALT Activity, glucose, urea, creatinine, total cholesterol, triglyceride, and HDL cholesterol levels were increased.
Whereas the AST and α- amylase activity showed significant reduction when compared with the control group.
The effect of IMC on the previous parameters was confirmed by the histological changes of liver and kidney.
In addition, NS oil supplementation showed a significant reduction of IMC adverse effect.
This result indicated that imidacloprid has the ability to damage liver and kidney functions and cause histological lesions in mice at the tested sublethal dose.
In addition, NS oil supplementation attenuated the IMC adverse effect which confirms its protective influence.
American Psychological Association (APA)
Ali, Rida Khamis Abd al-Razzaq. 2018. Effect of nigella sativa oil on the imidacloprid induced toxicity in male albino mice. Alexandria Journal of Agricultural Sciences،Vol. 63, no. 4, pp.239-250.
https://search.emarefa.net/detail/BIM-939544
Modern Language Association (MLA)
Ali, Rida Khamis Abd al-Razzaq. Effect of nigella sativa oil on the imidacloprid induced toxicity in male albino mice. Alexandria Journal of Agricultural Sciences Vol. 63, no. 4 (2018), pp.239-250.
https://search.emarefa.net/detail/BIM-939544
American Medical Association (AMA)
Ali, Rida Khamis Abd al-Razzaq. Effect of nigella sativa oil on the imidacloprid induced toxicity in male albino mice. Alexandria Journal of Agricultural Sciences. 2018. Vol. 63, no. 4, pp.239-250.
https://search.emarefa.net/detail/BIM-939544
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-939544