The detection of BK virus by quantitative PCR of plasma as screening test to identify renal transplant recipients at risk of BK virus nephropathy
Joint Authors
al-Asadi, Rad A.
al-Fatlawi, Sabah N.
al-Mualla, Ahmad Makki N.
Source
al-Kufa University Journal for Biology
Issue
Vol. 10, Issue 1 (30 Apr. 2018), pp.120-131, 12 p.
Publisher
University of Kufa Faculty of Science Department of live Sciences
Publication Date
2018-04-30
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract EN
Background: BK virus infection and nephritis are increasing problems in renal transplant recipients (RTRs).
Increasing prevalence of this infection and nephritis have been correlated with newer immunosuppressive agent in recent years.
Routine post-transplant screening for BK viremia prior to the occurrence of nephritis and the reduction in immunosuppressive therapy for subjects with BKV infection appear to be attractive objectives.
Objectives: This study performed to screening for BK virus in blood to identify RTRs at risk of development BKV associated nephritis (BKVN) .
Methods: In this case-control study, a total of 75 renal transplant recipients as a patients group, with 75 healthy adults as a control group, were involved in this study.
Quantitative detection of BKV viral load in blood by real time PCR assay was done for the both groups.
Results: This study revealed that 37% of the RTRs were positive for BK viremia by qPCR assay, While BKV has not detected in any one of the seventy five healthy persons of the control group, and about half (54%) of the recipients were identified as presumptive BKVN.
Conclusion: This study suggests that qPCR assay of blood is an important screening test for detection of BKV infection in RTRs.
American Psychological Association (APA)
al-Mualla, Ahmad Makki N.& al-Asadi, Rad A.& al-Fatlawi, Sabah N.. 2018. The detection of BK virus by quantitative PCR of plasma as screening test to identify renal transplant recipients at risk of BK virus nephropathy. al-Kufa University Journal for Biology،Vol. 10, no. 1, pp.120-131.
https://search.emarefa.net/detail/BIM-939791
Modern Language Association (MLA)
al-Mualla, Ahmad Makki N.…[et al.]. The detection of BK virus by quantitative PCR of plasma as screening test to identify renal transplant recipients at risk of BK virus nephropathy. al-Kufa University Journal for Biology Vol. 10, no. 1 (2018), pp.120-131.
https://search.emarefa.net/detail/BIM-939791
American Medical Association (AMA)
al-Mualla, Ahmad Makki N.& al-Asadi, Rad A.& al-Fatlawi, Sabah N.. The detection of BK virus by quantitative PCR of plasma as screening test to identify renal transplant recipients at risk of BK virus nephropathy. al-Kufa University Journal for Biology. 2018. Vol. 10, no. 1, pp.120-131.
https://search.emarefa.net/detail/BIM-939791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 130-131
Record ID
BIM-939791