Synthesis and antibacterial activities of some arabinofuranose-schiff bases derivatives

Abstract EN

As a continuous research for the discovery of new antibacterial agents due to the developing resistance toward conventional antibiotics, we reported a convenient synthetic approach for the preparation of methyl-α-D-arabinofuranoside shiff-bases.

A series of arabinose-Shiff bases were prepared through the trityl protection of the primary hydroxyl group of methyl-α-D-arabinofuranoside, benzoylation, the removal of the trityl protective group, tosylation, azidation, conversion to the amine in the presence of triphenylphosphine, condensing reaction with a variety of aromatic aldehydes, and subsequent debenzoylation.

New compounds were characterized by 1H NMR and FTIR spectroscopy.

Synthesised compounds were screened for antibacterial activity against several bacterial strains namely, Escherichia coli; Staphylococcus aureus; Bacillus subtilis; Candida albicans; Aspergillus niger, and they showed enhanced antibacterial activity.