Syzygium aromaticum l. And their effect on seizured chickens

Abstract EN

Cloves (Syzyguim Aromaticum L.) represent very interesting plant that has been used for many medicinal purposes such as treatment of convulsions due to its potent antioxidant activity.

The purpose of this study is to investigate the anti-convulsant effect of aqueous extract of Syzyguim Aromaticum L.

(cloves) at the doses (100,200,300 mg/kg), sodium valproate (200mg/kg) act as reference standard on serum total antioxidant capacity (T-AOC), gamma amino butyric acid (GABA) concentration and cholinesterase (ChE) activity in serum and brain, electrolytes (sodium Na+, potassium K+, chloride Cl- and total calcium Ca+2), glucose and total protein in serum of chicks after induction of seizures by pentylenetetrazole (PTZ), a plant used in traditional medicine as anticonvulsant.

72 chicks were recruited in this study were randomly divided into 6 groups of 12 each.

Negative control received normal saline, positive control was given only PTZ, group III was given sodium valproate orally.

The rest of three groups were given the extract at previous concentrations given through oral role.

Phytochemical analysis of the aqueous extract of cloves revealed the presence of psychoactive compounds such as flavonoids, cardiac glycoside, tannins, and alkaloids.

The present work suggest that the aqueous extract of plant had increased level of T-AOC,GABA and ChE in serum of chicks, which were decreased due to the susceptibility to PTZ induced seizure, and decreased the concentration of Na+ and glucose in the serum.

We reported that the cloves extract had quite low effect against PTZ induced seizure in spite of their positive effect on different biochemical parameters in serum; this may be due to the low concentration of doses used, which may be in adequate to produce obvious behavioral results