Acute toxicity impacts of diazinon and lambda cyhalothrin on mal albino rat

Abstract EN

The present study was carried out to investigate the impact of single sublethal oral dose of 36.5 mg/kg bw DZ(1/10 LD50; 365 mg/ kg bw) and 2.34 mg/kg bw LC(1/10 LD50; 23.4 mg/ kg bw) individually for 24 hr on some biochemical, hematological and immunological parameters in rat serum.

Results showed that DZ increase aspartate aminotransferase(AST) and alanine aminotransferase(ALT) activities, uric acid and creatinine concentration, while it reduced total cholesterol level.

LC treatment increased serum; AST and ALT activities, uric acid, creatinine and total cholesterol levels, while the triglycerides levels were significantly reduced.

Also, Hematological studies revealed that DZ treatment significantly increase WBCs and RBCs counts and Hb content, while Hct and PLT values showed no significant changes compared to control.

However, LC treatment didn’t induce any significant changes in all peripheral blood cell indicators except the Hct value which exhibited a significant elevation compared to control.

Both DZ and LC treatment showed no significant alterations in the erythrocytes indices.

Immunological studies showed that DZ caused significant decrease in lymphocytes counts(p < 0.05), while the peripheral neutrophils percentage and monocytes counts were significantly increased.

LC treatment enhanced the peripheral neutrophils and monocytes percentage, while lymphocytes counts showed no significant alteration.

The present result concluded that these insecticides have adversely affect biomarkers of rat serum, so it must be used wisely and carefully in order to prevent the hazardous side effects on mammalian targets.