Histological and histochemical changes induced by human chorionic gonadotropin on prostate of adult albino rats

Other Title(s)

التغيرات النسيجية و الكيمانسيجية المحدثة من استخدام هورمون القند المشيمي على بروستات الجردان البالغين

Joint Authors

Qasim, Walid H.
al-Sammak, Maha A.

Source

Iraqi Journal of Pharmacy

Issue

Vol. 15, Issue 1 (31 Dec. 2018)10 p.

Publisher

University of Mosul College of Pharmacy

Publication Date

2018-12-31

Country of Publication

Iraq

No. of Pages

10

Main Subjects

Pharmacology

Abstract EN

Aims of the study: To evaluate the histopathological changes induced by human chorionic gonadotropin (hCG) on the adult testis and to correlate the changes with the levels of testosterone, LH and FSH, as well as to assess their reversibility.

Methods: 80 adult male albino rats were divided into 4 groups; 3 treated and 1 control.

The treated groups were received 10, 50 or 100 IU/kg BW of hCG, while the controls received normal saline.

The doses were given twice weekly for 3 months via S.C.

injections.

Subsequently, on day 1, 30, 60 and 90 post therapy, blood samples and the testes were obtained for evaluation.

Results: Low dose of hCG caused increase in number of germ and Sertoli cells.

Contrary, higher doses decreased their population, and resulted in exfoliation of the germ cells.

Furthermore, reduction in the thickness of the tubular basement membrane, congestion of the inter-tubular blood vessels and interstitial bleeding were observed in the higher dose groups.

All the doses caused interstitial oedema, hyperplasia and hypertrophy of Leydig cells, as well as diminution in the collagen fibers.

All these changes were reversible within 3 months.

Conclusions: Only the low doses of hCG stimulate the spermatogenesis, whereas higher doses suppress sperm production.

American Psychological Association (APA)

Qasim, Walid H.& al-Sammak, Maha A.. 2018. Histological and histochemical changes induced by human chorionic gonadotropin on prostate of adult albino rats. Iraqi Journal of Pharmacy،Vol. 15, no. 1.
https://search.emarefa.net/detail/BIM-946297

Modern Language Association (MLA)

Qasim, Walid H.& al-Sammak, Maha A.. Histological and histochemical changes induced by human chorionic gonadotropin on prostate of adult albino rats. Iraqi Journal of Pharmacy Vol. 15, no. 1 (2018).
https://search.emarefa.net/detail/BIM-946297

American Medical Association (AMA)

Qasim, Walid H.& al-Sammak, Maha A.. Histological and histochemical changes induced by human chorionic gonadotropin on prostate of adult albino rats. Iraqi Journal of Pharmacy. 2018. Vol. 15, no. 1.
https://search.emarefa.net/detail/BIM-946297

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-946297