Antiphospholipid antibodies in patients with type 2 diabetes mellitus
Other Title(s)
الأجسام المضادة للشحوم الفوسفاتية لدى مرضى السكري من النوع الثاني
Joint Authors
Husayn, Ahmad Muayyad
Hasu, Nada Abd Allah
Fadil, Ali Salah
Source
Annals of the College of Medicine Mosul
Issue
Vol. 41, Issue 2 (30 Jun. 2019), pp.106-111, 6 p.
Publisher
University of Mosul College of Medicine-Mosul
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract EN
Patients with diabetes mellitus type 2 have a greater risk of accelerated atherosclerosis.
Antiphospholipid antibodies(aPL)are associated with greater risk for thrombosis.
To demonstrate the possible role of anticardiolipin(aCL) and anti-β2 glycoprotein(β2 GP1) antibodies in such patients, we investigate the presence of these antibodies in a group of type 2 diabetic patients.
Objectives: 1.
To investigate the presence of anticardiolipin IgM and IgG antibodies and anti-β2 GP1 IgG antibodies in diabetic patients and compare them with a control group.
2.
To analyze their potential implication in the occurrence of vasculopathy in such patients.
Patients and Methods: Fifty patients with type 2 diabetes mellitus and 33 healthy subjects were included in the study.
Each blood sample was tested for IgM, IgG aCL antibodies and for anti-β2 GP1 IgG antibodies.
Results: Seven patients were positive for aCL IgM, 6 were positive for aCL IgG and 4 patients were positive for anti-β2 GP1 IgG antibodies.
There was no differences in the means of IgM, IgG aCL and anti-β2 GP1 IgG antibodies titers in patients with complicated and uncomplicated diabetes mellitus.
Conclusion: The aCL and β2 GP1 antibodies positive titer means among type2 diabetics were significantly higher than non-diabetic subjects.
Positive but low titers of aCL and β2 GPI antibodies could suggest that these autoantibodies may play a minor role in the pathogenesis of atherosclerosis.
Low titers of aCL and β2 GPI antibodies were seen in complicated and non-complicated diabetic populations that probably lessen the importance of these autoantibodies as effective contributors in the pathogenesis of diabetic vasculopathy.
American Psychological Association (APA)
Hasu, Nada Abd Allah& Husayn, Ahmad Muayyad& Fadil, Ali Salah. 2019. Antiphospholipid antibodies in patients with type 2 diabetes mellitus. Annals of the College of Medicine Mosul،Vol. 41, no. 2, pp.106-111.
https://search.emarefa.net/detail/BIM-946588
Modern Language Association (MLA)
Hasu, Nada Abd Allah…[et al.]. Antiphospholipid antibodies in patients with type 2 diabetes mellitus. Annals of the College of Medicine Mosul Vol. 41, no. 2 (Jun. 2019), pp.106-111.
https://search.emarefa.net/detail/BIM-946588
American Medical Association (AMA)
Hasu, Nada Abd Allah& Husayn, Ahmad Muayyad& Fadil, Ali Salah. Antiphospholipid antibodies in patients with type 2 diabetes mellitus. Annals of the College of Medicine Mosul. 2019. Vol. 41, no. 2, pp.106-111.
https://search.emarefa.net/detail/BIM-946588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 110-111
Record ID
BIM-946588