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Histopathological study of platelete rich plasma for treatment of induced cutaneous ulcer in diabetic rabbits induced by streptozotocin
Other Title(s)
دراسة نسيجية مرضية للبلازما الغنية بالصفائح الدموية في علاج القرح الجلدية المحدثة في الأرانب المصابة بمرض السكري المستحدث بالستربتوزوتوسين
Joint Authors
Talib, Muhammad A.
Wahid, Zaynab
Source
Basrah Journal of Veterinary Research
Issue
Vol. 18, Issue 1 (30 Jun. 2019), pp.231-243, 13 p.
Publisher
University of Basrah College of Veterinary Medicine
Publication Date
2019-06-30
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Abstract EN
The present study investigates the effect of platelets rich plasma (PRP) on the healing of skin ulcers in rabbits in which diabetes mellitus (DM) was induced using Streptozotocin.
The study was applied on 12 adult rabbits of both sexes with a mean weight of 1000-1500 g.
They were divided randomly into two equal groups (six rabbits per group).
DM was induced in two groups by injected Streptozotosin 65 mg / kg B.W IV.
Ulcers were made in 3 cm length and 2 cm width in all rabbits in the gluteal region under the general Anesthesia by mixture of xylazine hydrochloride and ketamine hydrochloride in sterile conditions.
The first group was used as control; the second group was treated with platelets rich plasma on the site of ulcers.The first group in the 7 days, showed large ulcers and pus; in the 14 days, were ulcers continued with thickened epidermal.
Second group, in the 7days, showed skin ulcers with dermal thickening and a beginning of skin formation.
In the 14th days, treated group showed small ulcer remaining with dermal fibrosis.ELISA results have been shown the effect of platelets rich plasma on tumor necrosis factor alpha (TNFα) concentration in blood after 10 daysof skin lesions inducing.
The natural concentration of TNFα is 6.4 pg/ml in range (4.2-7.9) pg/ml.
The first group had a concentration below 5.3 pg/ml, due to the DM.
The second group was highly concentrated in 10.4 pg/ml.
The results of the histopathological and ELISA confirmed that there are a marked healing and elevating TNFα concentration in the treated group
American Psychological Association (APA)
Talib, Muhammad A.& Wahid, Zaynab. 2019. Histopathological study of platelete rich plasma for treatment of induced cutaneous ulcer in diabetic rabbits induced by streptozotocin. Basrah Journal of Veterinary Research،Vol. 18, no. 1, pp.231-243.
https://search.emarefa.net/detail/BIM-946659
Modern Language Association (MLA)
Talib, Muhammad A.& Wahid, Zaynab. Histopathological study of platelete rich plasma for treatment of induced cutaneous ulcer in diabetic rabbits induced by streptozotocin. Basrah Journal of Veterinary Research Vol. 18, no. 1 (2019), pp.231-243.
https://search.emarefa.net/detail/BIM-946659
American Medical Association (AMA)
Talib, Muhammad A.& Wahid, Zaynab. Histopathological study of platelete rich plasma for treatment of induced cutaneous ulcer in diabetic rabbits induced by streptozotocin. Basrah Journal of Veterinary Research. 2019. Vol. 18, no. 1, pp.231-243.
https://search.emarefa.net/detail/BIM-946659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 240-243
Record ID
BIM-946659