Histopathological evaluation of the 4, 4-(4, 5, 6, 7-Tetrahydro-(1, 2, 3-)‎ Selenadiazolo (4, 5 E)‎ Pyridine-4, 6-Diyl)‎ Bis (Benzene-1, 3-Diol)‎ on female rats in comparison with dipyrone

Abstract EN

Selenium (Se) is one of the vital nutritional components with main biological roles.

It acts as a prosthetic group in many enzymes like glutathione peroxidase enzyme and thioredoxin reductase enzyme.

The aim of the present study to investigate the histological effects of 4̄,4̄̄ -(4,5,6,7-Tetrahydro- [1,2,3-] Selenadiazolo [4,5 E] Pyridine-4,6-Diyl) Bis(Benzene-1,3-Diol)(T) compare with Dipyrone (Di) on kidney, liver and stomach.

Healthy female rats divided into four groups received 50mg/kg BW of T (T group), Di (Di group), both T and Di (T&Di) dissolved in 2 ml of distilled water(DW), the forth group control received 2 mL of (DW) for 30 days.

The samples of liver, kidney and stomach were fixed in 10%formalin, and the histological sections and staining were prepared in the pharmacy college central lab for histopathological examination.

The results indicated that Di group showed disarrangement of hepatic architecture and sinusoids narrowed of the liver.

Section of the kidneys reveal shrinkage in glomerular content and misshaped of cuboidal lining epithelial.

Stomach sections showed destruction of gastric pits and increased number of fundic glands.

T group liver sections incomplete disappearance of hepatocyte radiation.

Renal Section of T treated group rat’s disappearance of Bowman’s capsule; stomach Sections showed complete disappearance of epithelial cells of the gastric pit.

T&Di group sections exhibit disappearance of hepatocytes normal radiation architecture phenomena, also there is some hemorrhages.

Renal histological sections showed absences of walls of cuboidal lining epithelium with enlarged nuclei.

It can be concluded that T compound has low destructive effects on the test organs compare with Di and control group.

Administrations of both treatments have no benefit effects.