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Effect of fusarium graminarum silver-nanoparticles on IL-10 and INF-γ cytokines levels in the mice by Leishmania donovani in vivo
Joint Authors
Muhammad, Saba Tahir
Ghadi, Haydar Hasan
Sulayman, Nida Muhammad
Kamal, Sura Basil
Aja, Hasan Ali
Source
Iraqi Journal of Biotechnology
Issue
Vol. 18, Issue 2 (31 May. 2019), pp.106-115, 10 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2019-05-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
Leishmaniasis remains one of the fatal diseases worldwide, and the conventional antileishmanial therapies are toxic and most are expensive.
Biological silver nanoparticles possess broad-spectrum antimicrobial activities and could be a future alternative to current antimicrobial agents.
In the present study an approach was made to synthesize silver nanoparticles (AgNps) using a Fusarium graminarum fungus.
The present study it investigates the efficiency of silver nanoparticles against Leishmania donovani compared with pentostam drug in vivo by measuring the levels of immune cytokines (IL-10 and IFN-γ) in serum infected mice and treatment with AgNPs (0.1 ml / day) and comparisons with pentostam drug (0.01ml / day) after 21 days of treatment.
The results showed that the level of IFN-γ in treating with AgNPs increased significantly in third weeks, compared to the pentostam group.
When treated with pentostam/AgNPs together, there is a gradual decrease in the level of IFN-γ, compared with negative control.
Also a significant increase occurs in the IL-10 level within 21 days when mice were treated with AgNPs compared with pentostam.
It could be conclude that silver nanoparticles induce pro and anti-inflammatory cytokines also it safety, nontoxic and has a good anti-parasitic activity, it can be used as antileishmanial drug or can be used as supportive treatment of visceral leishmaniasis.
American Psychological Association (APA)
Muhammad, Saba Tahir& Ghadi, Haydar Hasan& Sulayman, Nida Muhammad& Kamal, Sura Basil& Aja, Hasan Ali. 2019. Effect of fusarium graminarum silver-nanoparticles on IL-10 and INF-γ cytokines levels in the mice by Leishmania donovani in vivo. Iraqi Journal of Biotechnology،Vol. 18, no. 2, pp.106-115.
https://search.emarefa.net/detail/BIM-947114
Modern Language Association (MLA)
Muhammad, Saba Tahir…[et al.]. Effect of fusarium graminarum silver-nanoparticles on IL-10 and INF-γ cytokines levels in the mice by Leishmania donovani in vivo. Iraqi Journal of Biotechnology Vol. 18, no. 2 (May. 2019), pp.106-115.
https://search.emarefa.net/detail/BIM-947114
American Medical Association (AMA)
Muhammad, Saba Tahir& Ghadi, Haydar Hasan& Sulayman, Nida Muhammad& Kamal, Sura Basil& Aja, Hasan Ali. Effect of fusarium graminarum silver-nanoparticles on IL-10 and INF-γ cytokines levels in the mice by Leishmania donovani in vivo. Iraqi Journal of Biotechnology. 2019. Vol. 18, no. 2, pp.106-115.
https://search.emarefa.net/detail/BIM-947114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 113-115
Record ID
BIM-947114