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Inhibitor activity of some coumarin derivatives on glycosyltransferases produce from Streptococcus pneumoniae P 3
Joint Authors
al-Halbusi, Rafal Ismail Ali
al-Jumayli, Isam Fadil A.
al-Qazzaz, Abd al-Karim Abd al-Razzaq Abd al-Wahhab
Source
Iraqi Journal of Biotechnology
Issue
Vol. 18, Issue 2 (31 May. 2019), pp.142-149, 8 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2019-05-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
This study was conducted with the aim to evaluate the inhibitor activity of some coumarin derivatives on glycosyltransferases produced by Streptococcus pneumoniae P3.
The increased occurrence of S.
pneumoniae strains resistant to -lactam antibiotics has become a worldwide health problem.
The results showed that the Coumarin and its derivatives in the concentration 100 µg/ml applied on Streptococcus pneumoniae P3 to estimate these affecting on the bacterial ability to produce enzyme by measuring the value of enzyme activity it decreased the enzyme activity from 178 unit/ml to (57.9 , 68.90, 72.65 and 62.34) unit/ml with inhabitation ratio 32.52 , 38.70 , 40.81 and 35.032 % respectively of Inhibitor coumarin, 7-ethyl-4-methyl coumarin, 4,7 dimethyl-6-nitro coumarin and7-hydroxy-4-methyl coumarin respectively.
The study concluded that thus prompting the present more extensive investigation of coumarin derivatives.
Attention is given to structure-activity relationships with emphasis on the aromatic oxygenation patterns among this class of secondary metabolites.
American Psychological Association (APA)
al-Halbusi, Rafal Ismail Ali& al-Jumayli, Isam Fadil A.& al-Qazzaz, Abd al-Karim Abd al-Razzaq Abd al-Wahhab. 2019. Inhibitor activity of some coumarin derivatives on glycosyltransferases produce from Streptococcus pneumoniae P 3. Iraqi Journal of Biotechnology،Vol. 18, no. 2, pp.142-149.
https://search.emarefa.net/detail/BIM-947131
Modern Language Association (MLA)
al-Halbusi, Rafal Ismail Ali…[et al.]. Inhibitor activity of some coumarin derivatives on glycosyltransferases produce from Streptococcus pneumoniae P 3. Iraqi Journal of Biotechnology Vol. 18, no. 2 (May. 2019), pp.142-149.
https://search.emarefa.net/detail/BIM-947131
American Medical Association (AMA)
al-Halbusi, Rafal Ismail Ali& al-Jumayli, Isam Fadil A.& al-Qazzaz, Abd al-Karim Abd al-Razzaq Abd al-Wahhab. Inhibitor activity of some coumarin derivatives on glycosyltransferases produce from Streptococcus pneumoniae P 3. Iraqi Journal of Biotechnology. 2019. Vol. 18, no. 2, pp.142-149.
https://search.emarefa.net/detail/BIM-947131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 148-149
Record ID
BIM-947131