Clinical complications of beta-thalassemia major
Other Title(s)
المضاعفات الناتجة عن مرض الثلاسيميا الكبرى
Joint Authors
Shawkat, Ali Jalal
Juwayd, Ahmad Hamid
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 2 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
Beta thalassemia syndrome (β-TM) syndrome is a group of hereditary blood disorders that are mainly characterized by reduction or absence of β-globin chain synthesis.
Without iron chelation therapy (ICT) the regular blood transfusion would increase the iron stores to several times.
Endocrine glands are vulnerable to iron overload causing endocrine dysfunction.
Iron deposition within the parathyroid gland causes hypoparathyroidism particularly after ten years of age.
Pancreatic islets are very susceptible to oxidative damage due to iron overload; their high divalent metal expression makes them highly susceptible to iron-catalyzing oxidative stress.
The pathogenicity of osteopathy in β-TM is multifactorial comprising environmental (diet and lifestyle), iatrogenic (medicines), genetic and acquired factors (expansion of bone marrow, hemochromatosis, deficiency of growth hormone, hepatitis and hypogonadism).
The increase in blood transfusion and RBCs break down in addition to iron accumulation and deposition are the main factors causing splenomegaly.
Liver disease is one of the major complications affecting patients with β‐TM.Liver damage is multifactorial with iron overload is considered the main causative factor, as well as hepatitis C (HCV) and hepatitis B (HBV) infections which are acquired on recurrent blood transfusions.
The free radicals of deposited iron overcome the cellular antioxidant mechanisms resulting in peroxidative cellular injury.
As a result, iron overload is the leading cause of left ventricular cardiomyopathy development.
American Psychological Association (APA)
Shawkat, Ali Jalal& Juwayd, Ahmad Hamid. 2019. Clinical complications of beta-thalassemia major. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-947272
Modern Language Association (MLA)
Shawkat, Ali Jalal& Juwayd, Ahmad Hamid. Clinical complications of beta-thalassemia major. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 2 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-947272
American Medical Association (AMA)
Shawkat, Ali Jalal& Juwayd, Ahmad Hamid. Clinical complications of beta-thalassemia major. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 2, pp.1-8.
https://search.emarefa.net/detail/BIM-947272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-8
Record ID
BIM-947272