Ex-vivo absorption study of a novel dabigatran etexilate loaded nanostructured lipid carrier using non-everted intestinal sac model

Other Title(s)

دراسة النفاذية الحيوية خارج الجسم لحاملات الدهون النانوية الجديدة المحملة بالدابيغاتران أيتكزيليت باستخدام نموذج الكيس المعوي غير المقلوب للخارج

Joint Authors

Abd, Haytham Najm al-Din
Husayn, Ahmad Abbas

Source

Iraqi Journal of Pharmaceutical Sciences

Issue

Vol. 28, Issue 2 (31 Dec. 2019), pp.37-45, 9 p.

Publisher

University of Baghdad College of Pharmacy

Publication Date

2019-12-31

Country of Publication

Iraq

No. of Pages

9

Main Subjects

Medicine

Topics

Abstract EN

The purpose of the study was to develop Dabigatran Etexilate loaded nanostructured lipid carriers (DE-NLCs) using Glyceryl monostearate and Oleic acid as lipid matrix, and to estimate the potential of the developed delivery system to improve oral absorption of low bioavailability drug, different Oleic acid ratios effect on particle size, zeta potential, entrapment efficiency and loading capacity were studied, the optimized DE-NLCs shows a particle size within the nanorange, the zeta potential (ZP) was 33.81±0.73mV with drug entrapment efficiency (EE%) of 92.42±2.31% and a loading capacity (DL%) of 7.69±0.17%.

about 58.5% of drug was released in 8hr in a controlled manner, the ex-vivo intestinal permeation study using the non-everted sac model shows four folds increment in the permeation of DE-NLCs compared to dabigatran etexilate suspension (DE-S).

American Psychological Association (APA)

Abd, Haytham Najm al-Din& Husayn, Ahmad Abbas. 2019. Ex-vivo absorption study of a novel dabigatran etexilate loaded nanostructured lipid carrier using non-everted intestinal sac model. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 2, pp.37-45.
https://search.emarefa.net/detail/BIM-947283

Modern Language Association (MLA)

Abd, Haytham Najm al-Din& Husayn, Ahmad Abbas. Ex-vivo absorption study of a novel dabigatran etexilate loaded nanostructured lipid carrier using non-everted intestinal sac model. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 2 (2019), pp.37-45.
https://search.emarefa.net/detail/BIM-947283

American Medical Association (AMA)

Abd, Haytham Najm al-Din& Husayn, Ahmad Abbas. Ex-vivo absorption study of a novel dabigatran etexilate loaded nanostructured lipid carrier using non-everted intestinal sac model. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 2, pp.37-45.
https://search.emarefa.net/detail/BIM-947283

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 35-36

Record ID

BIM-947283