Ex-vivo absorption study of a novel dabigatran etexilate loaded nanostructured lipid carrier using non-everted intestinal sac model
Other Title(s)
دراسة النفاذية الحيوية خارج الجسم لحاملات الدهون النانوية الجديدة المحملة بالدابيغاتران أيتكزيليت باستخدام نموذج الكيس المعوي غير المقلوب للخارج
Joint Authors
Abd, Haytham Najm al-Din
Husayn, Ahmad Abbas
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 2 (31 Dec. 2019), pp.37-45, 9 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
The purpose of the study was to develop Dabigatran Etexilate loaded nanostructured lipid carriers (DE-NLCs) using Glyceryl monostearate and Oleic acid as lipid matrix, and to estimate the potential of the developed delivery system to improve oral absorption of low bioavailability drug, different Oleic acid ratios effect on particle size, zeta potential, entrapment efficiency and loading capacity were studied, the optimized DE-NLCs shows a particle size within the nanorange, the zeta potential (ZP) was 33.81±0.73mV with drug entrapment efficiency (EE%) of 92.42±2.31% and a loading capacity (DL%) of 7.69±0.17%.
about 58.5% of drug was released in 8hr in a controlled manner, the ex-vivo intestinal permeation study using the non-everted sac model shows four folds increment in the permeation of DE-NLCs compared to dabigatran etexilate suspension (DE-S).
American Psychological Association (APA)
Abd, Haytham Najm al-Din& Husayn, Ahmad Abbas. 2019. Ex-vivo absorption study of a novel dabigatran etexilate loaded nanostructured lipid carrier using non-everted intestinal sac model. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 2, pp.37-45.
https://search.emarefa.net/detail/BIM-947283
Modern Language Association (MLA)
Abd, Haytham Najm al-Din& Husayn, Ahmad Abbas. Ex-vivo absorption study of a novel dabigatran etexilate loaded nanostructured lipid carrier using non-everted intestinal sac model. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 2 (2019), pp.37-45.
https://search.emarefa.net/detail/BIM-947283
American Medical Association (AMA)
Abd, Haytham Najm al-Din& Husayn, Ahmad Abbas. Ex-vivo absorption study of a novel dabigatran etexilate loaded nanostructured lipid carrier using non-everted intestinal sac model. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 2, pp.37-45.
https://search.emarefa.net/detail/BIM-947283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 35-36
Record ID
BIM-947283