Synthesis and characterizations of dipeptide derivative of gentamicin
Other Title(s)
تحضير و توصيف مشتق ثنائي الببتيد من الجنتاميسين
Author
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 2 (31 Dec. 2019), pp.73-82, 10 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Topics
Abstract EN
The target derivative is gentamicin linked with L-Val- L-Ala by an ester linkage.
It was synthesized by esterification method, which included the reaction of hydroxyl group on (carbon No.5) of gentamicin with the acid chloride of the corresponding dipeptide.
The preparation of new derivative of gentamicin involved protection of the primary and secondary amino groups of gentamicin, by ethylchloroformate (ECF) to give N-carbomethoxy gentamicin which was used for further chemical synthesis involving the free hydroxyl groups.The prepared dipeptide (L-Val- L-Ala) by conventional solution method in the presence of DCC & HOBt then reacted with thionyl chloride to prepare acid chloride of dipeptides, then after, linked by ester linkage to N-protection gentamicin in present pyridine as base, finally deprotection the amino group of synthesized compound by using trifluoroacetic acid (TFA) in the presence anisole.The characterization of the titled compound was performed utilizing FTIR spectroscopy, CHNO elemental analysis, and by measurements of their physical properties.
American Psychological Association (APA)
Khudayr, Awn Dali. 2019. Synthesis and characterizations of dipeptide derivative of gentamicin. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 2, pp.73-82.
https://search.emarefa.net/detail/BIM-947294
Modern Language Association (MLA)
Khudayr, Awn Dali. Synthesis and characterizations of dipeptide derivative of gentamicin. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 2 (2019), pp.73-82.
https://search.emarefa.net/detail/BIM-947294
American Medical Association (AMA)
Khudayr, Awn Dali. Synthesis and characterizations of dipeptide derivative of gentamicin. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 2, pp.73-82.
https://search.emarefa.net/detail/BIM-947294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 82
Record ID
BIM-947294