Solubility and dissolution enhancement of atorvastatin calcium using solid dispersion adsorbate technique
Other Title(s)
تحسين الذوبانية و معدل الذوبان للاتروفاستاتين كالسيوم باستخدام تقنية الصلب المنتشرالممتز
Joint Authors
Ali, Samir Khalid
al-Khudayri, Iman Bakr Hazim
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 2 (31 Dec. 2019), pp.105-114, 10 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
Atorvastatin (ATR) is a poorly soluble anti-hyperlipidemic drug.
The drug belongs to the class II group according to the biopharmaceutical classification system (BCS) with low bioavailability due to its low solubility.
Solid dispersions adsorbate is an effective technique for enhancing the solubility and dissolution of poorly soluble drugs.The present study aims to enhance the solubility and dissolution rate of ATR using solid dispersion adsorbate technique in comparison with ordinary solid dispersion.
polyethylene glycol 4000 (PEG 4000), polyethylene glycol 6000 (PEG 6000), Poloxamer188 and Poloxamer 407were used as hydrophilic carriers besides Aerosil 200, Aerosil 300 and magnesium aluminium silicate (MAS) as adsorbents.
All solid dispersion adsorbate (SDA) formulas were prepared in ratios of 1:1:1 (drug: carrier: adsorbent) and evaluated for their water solubility, percentage yield, drug content, , dissolution, crystal lattice using X-ray powder diffraction (XRD) and Differential Scanning Calorimetry (DSC) studies and Fourier Transform Infrared Spectroscopy (FTIR) for determination the drug-carrier- adsorbate interaction.The prepared (SDA) showed improvement of drug solubility in all prepared formula.
The best result was obtained with formula SDA12 (ATR: Poloxamer407: MAS 1:1:1) that showed 8.07 and 5.38 fold increase in solubility compared to solubility of pure ATR and solid dispersion(SD4) (Atorvastatin: Poloxamer 407 1:1) respectively due to increased wettability and reduced crystallinity of the drug which leads to improving drug solubility and dissolution.
American Psychological Association (APA)
Ali, Samir Khalid& al-Khudayri, Iman Bakr Hazim. 2019. Solubility and dissolution enhancement of atorvastatin calcium using solid dispersion adsorbate technique. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 2, pp.105-114.
https://search.emarefa.net/detail/BIM-947302
Modern Language Association (MLA)
Ali, Samir Khalid& al-Khudayri, Iman Bakr Hazim. Solubility and dissolution enhancement of atorvastatin calcium using solid dispersion adsorbate technique. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 2 (2019), pp.105-114.
https://search.emarefa.net/detail/BIM-947302
American Medical Association (AMA)
Ali, Samir Khalid& al-Khudayri, Iman Bakr Hazim. Solubility and dissolution enhancement of atorvastatin calcium using solid dispersion adsorbate technique. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 2, pp.105-114.
https://search.emarefa.net/detail/BIM-947302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 113-114
Record ID
BIM-947302