Design, synthesis and cytotoxicity study of primary amides as histone deacetylase inhibitors
Other Title(s)
تصميم، تخليق، و دراسة السمية الخلوية للأمايدات الأولية كمثبطات لأنزيم الهيستون دي اسيتيليز
Joint Authors
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 2 (31 Dec. 2019), pp.151-158, 8 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare.
This paper describes the synthesis of the primary amide derivatives adipic monoanilide amide and pimelic monoanilide amide (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type.
Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line
American Psychological Association (APA)
al-Amili, Durayd Hamid& Muhammad, Muhammad Hasan. 2019. Design, synthesis and cytotoxicity study of primary amides as histone deacetylase inhibitors. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 2, pp.151-158.
https://search.emarefa.net/detail/BIM-947312
Modern Language Association (MLA)
al-Amili, Durayd Hamid& Muhammad, Muhammad Hasan. Design, synthesis and cytotoxicity study of primary amides as histone deacetylase inhibitors. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 2 (2019), pp.151-158.
https://search.emarefa.net/detail/BIM-947312
American Medical Association (AMA)
al-Amili, Durayd Hamid& Muhammad, Muhammad Hasan. Design, synthesis and cytotoxicity study of primary amides as histone deacetylase inhibitors. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 2, pp.151-158.
https://search.emarefa.net/detail/BIM-947312
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 157-158
Record ID
BIM-947312