Use of human umbilical cord serum to treat animal skin burns
Other Title(s)
استعمال مصل الحبل السري البشري لعلاج حروق جلد الحيوان
Joint Authors
Ismail, Isra
Kassab, Hanan Jalal
al-Rammahi, Intisar J.
al-Asadi, Ala A.
al-Musawi, Sawsan
Ahmad, Rawnaq
al-Sultani, Durays
Mirdaw, Maysun Abd al-Zahrah
Source
Iraqi Journal of Pharmaceutical Sciences
Issue
Vol. 28, Issue 2 (31 Dec. 2019), pp.165-173, 9 p.
Publisher
University of Baghdad College of Pharmacy
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Abstract EN
The objective of the study was to test the hypothesis that human umbilical cord blood crude serum applied topically may promote an early healing for animal models with burn injury.
Human umbilical cord serum HUCS was collected and screened for transmitted diseases such as hepatitis B, hepatitis C and HIV.
The HUCS was subjected to microbial testing to demonstrate the presence or absence of viable contaminating microorganisms.
Mice (no=45) and rabbits (n=16) were scalded by boiling water then treated with HUCS in comparison to untreated animals.
Another group of rabbits (n=24) were subjected to hot water (70°C) and 1N NaOH and treated with HUCS in comparison to cetrimide 0.5% cream treated group and control group (without treatment).
Topical application of HUCS promoted the healing process; complete healing was seen after 10 days in the mice group and 7 days in the rabbit group.
Cetrimide group applied to the second rabbit group showed slow healing and needed 10 days for hair regrowth.
Control group in both mice and the two rabbits’ group, showed very slow response and the burn area diameter remained the same for over 10 days, and no hair regrowth was observed after 10 days.
In conclusion the results of the current study indicated that HUCS is a promising therapy for healing of burns caused by boiling water alone or by alkali with hot water.
More clinical trials are needed to explore the long-term effects after UCS use and incorporation of HUCS in suitable dosage form.
American Psychological Association (APA)
al-Rammahi, Intisar J.& Kassab, Hanan Jalal& Mirdaw, Maysun Abd al-Zahrah& al-Asadi, Ala A.& al-Musawi, Sawsan& Ahmad, Rawnaq…[et al.]. 2019. Use of human umbilical cord serum to treat animal skin burns. Iraqi Journal of Pharmaceutical Sciences،Vol. 28, no. 2, pp.165-173.
https://search.emarefa.net/detail/BIM-947325
Modern Language Association (MLA)
al-Rammahi, Intisar J.…[et al.]. Use of human umbilical cord serum to treat animal skin burns. Iraqi Journal of Pharmaceutical Sciences Vol. 28, no. 2 (2019), pp.165-173.
https://search.emarefa.net/detail/BIM-947325
American Medical Association (AMA)
al-Rammahi, Intisar J.& Kassab, Hanan Jalal& Mirdaw, Maysun Abd al-Zahrah& al-Asadi, Ala A.& al-Musawi, Sawsan& Ahmad, Rawnaq…[et al.]. Use of human umbilical cord serum to treat animal skin burns. Iraqi Journal of Pharmaceutical Sciences. 2019. Vol. 28, no. 2, pp.165-173.
https://search.emarefa.net/detail/BIM-947325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 172-173
Record ID
BIM-947325