The protective effect of lactobacillus against ciprofloxacin and levofloxacin associated diarrhea in sample of Iraqi patients

Abstract EN

Fluoroquinolones drugs are important classes of wide spectrum antibacterial agents that are active against a wide range of Gram-negative and Gram-positive pathogens; they are divided into four generations.

Specific types of antibiotics have been associated with side effect like diarrhea, this called (collateral damage), which may occur due to drug-resistant organisms and the unwanted development of colonization or infection with multidrug-resistant organisms.

This damage is mostly related to levofloxacin and Ciprofloxacin.

The aim of the current study was to compare the incidence of collateral damage between two quinolone antibiotic derivatives (ciprofloxacin and levofloxacin) and to evaluate the activity of lactobacillus to reduce the collateral damage.

This study was carried out on 100 patients.

Administration of ciprofloxacin, levofloxacin each alone or in combination with lactobacillus; the character of diarrhea and the grade of diarrhea was studied before and after 10 days of administration each dosing protocol.

The results for this study, there are a significant increase in the incidence of diarrhea for all groups when comparison between before and after treatment diarrhea was made; a number of patients with diarrhea in group 1 after finish the treatment was not significantly higher when compared with group 2 (P>0.05); meanwhile, number of patients with diarrhea in group 4 after finish the treatment was significantly lower when compared with group 3 (P<0.05).

it can concluded that , The use of ciprofloxacin and levofloxacin associated with incidence of collateral damage represented as diarrhea and levofloxacin is the least risk of this damage, and using of lactobacillus with levofloxacin was better results than the other three groups.