Evaluation of some biomarkers of autistic children in Thi-Qar Province- Iraq

Abstract EN

Several studies have been carried out to find a candidate biomarkers linked to the development of autism disorder.

The aim of this study is to provide an overview of the various biomarkers and discuss it is roles in the pathogenesis of autism.

Because of, early analysis may lead to early estimation and prevention for the autistic neurodevelopment disorders rather than only to a symptom category.

This study investigates some blood standers and concentrations of trace elements and toxic metals as bio marker for autism disorder indicators.

The study was involved 95 autistic children aged 1–14 years, included 77 males (81%) and 18(19%) females.

The results were showed the age group of 3-5 years recorded the highest percentage (41.05%).

Blood analysis results showed blood groups that were RH+ recorded the highest percentage for B+, A+, O+ and AB+ with 30%, 28%, 26% , and 5% respectively.

While that were RH_ noted the lower percentage for O_ (7%), A_ (4%), AB_ and B_ didn’t record any percentage.

Blood cell counts (CBC) of WBC in autistic children were not significantly different from those of the control group, with the sole exception of a significant trend for neutrophil and lymphocyte, slightly lower in the autistic group (p≤0.05).

While, RBC variables showed significant differences regarding HGB, HCT, MCV and MCH in autistic children compare with control group(p≤0.05).

The study included measurements of trace elements (Copper and Zinc) in whole blood and toxic element (Lead) in serum.

The results were showed elevation in level of this elements in all age groups with significand deference between patients and control (p≤0.05).

These result could be correlated with the severity of autism.

These findings suggest that biomarkers for neurodevelopment may be critical and improve early diagnosis and probably for therapy.

More biochemical investigation, or any other test that helps diagnose the abnormality disorder in children.