The minimum inhibitory concentration of different antifungal agents against candida species

Abstract EN

Five antifungal drugs (terbinafine, griseofulvin, nystatin, ketoconazole and itraconazole) were tested in vitro against three Candida species which were: (Candida albicans, C.

tropicalis and C.

parapsilosis) for detection their Minimum Inhibitory Concentration (MIC).

First the Antifungal inhibitory activity was tested by disc diffusion for the tested Candida spices, the result shows that the C.

parapsilosis was the most sensitive yeast, especially to ketoconazole which have the most inhibitory activity with zone of inhibition of (2.26cm), followed by nystatin with zone of inhibition of (2.05cm), while C.

albicans was more sensitive to nystatin with zone of inhibition of (2.01cm) followed by ketoconazole with zone of inhibition of (1.86 cm), The result showed that nystatin was the most effective antifungal drug against C.

albicans and C.

parapsilosis with (MIC) range (0.383 and 0.443 μg/ml) respectively, while ketoconazole showed the most inhibitory effect on C.

tropicalis with MIC range (0.248 μg/ml)., while C.

tropicalis has MIC of ketoconazole at 5th fold of dilution which was 0.248, followed by terbinafine and itraconazole which was (0.383 and 0.376) respectively.