The histological changes induced by cytarabine on rabbits livers (with and without vitamin e administration)
Other Title(s)
التغييرات النسيجية التي يحدثها عقار السيتارابين على أنسجة الكبد في الأرانب (مع و بدون إعطاء فيتامين هـ)
Joint Authors
al-Jammas, Sayf
al-Siraj, Iyad Abd al-Rahman
Source
Iraqi Journal of Veterinary Sciences
Issue
Vol. 34, Issue 1 (30 Jun. 2020), pp.9-13, 5 p.
Publisher
University of Mosul College of Veterinary Medicine
Publication Date
2020-06-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
The present study was intended to determine the histological changes induced by Cytarabine drug on the structure of rabbit's livers and the protective effects of vitamin E on these histological changes.
The treated group with daily intraperitoneal dose of (50 mg/kg body weight) of Cytarabine alone, showed a massive histological change represented by infiltration of mononuclear inflammatory cells, epithelioid cell and Kupffer's cells in hepatic tissue.
Fibrosis in portal area, congestion of blood vessels as well as hyperplasia of bile canaliculi and coagulative necrosis of hepatocytes were also noticed in other sections.
While the group that received protective (800 IU of vitamin E) prior to each Cytarabine injection, showed a considerable histological improvement than the group received Cytarabine alone, as the histological sections of this group showed a nearly normal histological architecture of the liver that represented by normal arrangement of hepatic cords, no fibrosis no congested blood vessels were seen.
though distension of hepatic sinusoids and coagulative necrosis of some hepatocytes were still observed.
The present study suggested that vitamin E is an effective chemo-protective agent against hepatotoxicity when used as a protective agent prior to Cytarabine drug taken.
American Psychological Association (APA)
al-Jammas, Sayf& al-Siraj, Iyad Abd al-Rahman. 2020. The histological changes induced by cytarabine on rabbits livers (with and without vitamin e administration). Iraqi Journal of Veterinary Sciences،Vol. 34, no. 1, pp.9-13.
https://search.emarefa.net/detail/BIM-948780
Modern Language Association (MLA)
al-Jammas, Sayf& al-Siraj, Iyad Abd al-Rahman. The histological changes induced by cytarabine on rabbits livers (with and without vitamin e administration). Iraqi Journal of Veterinary Sciences Vol. 34, no. 1 (2020), pp.9-13.
https://search.emarefa.net/detail/BIM-948780
American Medical Association (AMA)
al-Jammas, Sayf& al-Siraj, Iyad Abd al-Rahman. The histological changes induced by cytarabine on rabbits livers (with and without vitamin e administration). Iraqi Journal of Veterinary Sciences. 2020. Vol. 34, no. 1, pp.9-13.
https://search.emarefa.net/detail/BIM-948780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 13
Record ID
BIM-948780