Histopathological effect of fluoxetine drug on the brain of pregnant mice and their embryos

Other Title(s)

التأثيرات النسجية المرضية لعقار الفلوكستين على دماغ الفئران الحوامل و أجنتها

Author

Salih, Bayda Abd al-Aziz Muhammad

Source

Iraqi Journal of Veterinary Sciences

Issue

Vol. 34, Issue 1 (30 Jun. 2020), pp.71-76, 6 p.

Publisher

University of Mosul College of Veterinary Medicine

Publication Date

2020-06-30

Country of Publication

Iraq

No. of Pages

6

Main Subjects

Biology

Abstract EN

The present study was designed to identify the histopathological effect of fluoxetine (fluoxetine hydrochloride) on the pregnant mice brain and their fetuses as well as recording weight changes at doses of 60 and 80 mg/kg of body weight which were administrated to the pregnant mice from the 7th up to the 18th day of pregnancy and once a day.

The results showed histopathological lesions in the adult pregnant mice brain at the dose of 60 mg/kg.

induced massive necrotic area of neurons in the cerebral cortex, necrosis of the molecular layer cells while the dose of 80 mg/kg the changes include vasogenic edema in the sub cortical area, severe degeneration and necrosis of the cortex.

The lesions in cerebellum were more severe than recorded in the cerebrum.

The results also showed the presence of many lesions in the fetus brain at the dose 60 mg/kg and they were degeneration, necrosis of many neurons in the cerebrum while at the dose of 80 mg/kg.

There were increase of degeneration and necrosis in the cortical area of fetus brain.

In conclusion, the use of fluoxetine in pregnant mice caused decrease in body weight and Histopathological changes in the brain of both of the mothers and their embryos, thus the use of antidepressant by pregnant woman can be harmful for the mothers and the fetus.

American Psychological Association (APA)

Salih, Bayda Abd al-Aziz Muhammad. 2020. Histopathological effect of fluoxetine drug on the brain of pregnant mice and their embryos. Iraqi Journal of Veterinary Sciences،Vol. 34, no. 1, pp.71-76.
https://search.emarefa.net/detail/BIM-948789

Modern Language Association (MLA)

Salih, Bayda Abd al-Aziz Muhammad. Histopathological effect of fluoxetine drug on the brain of pregnant mice and their embryos. Iraqi Journal of Veterinary Sciences Vol. 34, no. 1 (2020), pp.71-76.
https://search.emarefa.net/detail/BIM-948789

American Medical Association (AMA)

Salih, Bayda Abd al-Aziz Muhammad. Histopathological effect of fluoxetine drug on the brain of pregnant mice and their embryos. Iraqi Journal of Veterinary Sciences. 2020. Vol. 34, no. 1, pp.71-76.
https://search.emarefa.net/detail/BIM-948789

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 75-76

Record ID

BIM-948789