Synthesis, spectroscopic study and biological activity of some new heterocyclic compounds derived from sulfadiazine
Joint Authors
Abd Allah, Midya Nuri
Hasan, Sangar A.
Source
ZANCO Journal of Pure and Applied Sciences
Issue
Vol. 31, Issue 6 (31 Dec. 2019), pp.92-109, 18 p.
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
18
Main Subjects
Abstract EN
This study illustrates the synthesis and spectroscopic study of new β-lactam and novel Pyrrolone derivatives with the study of their antioxidant and antibacterial activities.
This study included two major steps, the first step involved the synthesis of imine derivatives (3a-j) from sulfadiazine.
The second step contained the synthesis of 2-Azetidinone (4a-j) and Pyrrolone (5a-j) heterocyclic compounds that have been generated through the reaction between synthesized imine derivatives with chloroacetyl chloride and fumaryl chloride in the presence of triethylamine, respectively.
The structures of the synthesized compounds were confirmed on the basis of their spectral data such as FT-IR, 1H-NMR and 13C-NMR spectra, which provided the expected frequencies and signals.
Lastly, all products were screened for the antioxidant activity and against two kinds of bacteria Staphylococcus aureus G (+ve) and Escherichia coli G (-ve) microorganisms.
The products showed lower to high antioxidant activity as compared to standard ascorbic acid.
Some of the products evaluated inactive and others slight to high activity against both kinds of bacteria.
American Psychological Association (APA)
Hasan, Sangar A.& Abd Allah, Midya Nuri. 2019. Synthesis, spectroscopic study and biological activity of some new heterocyclic compounds derived from sulfadiazine. ZANCO Journal of Pure and Applied Sciences،Vol. 31, no. 6, pp.92-109.
https://search.emarefa.net/detail/BIM-949373
Modern Language Association (MLA)
Hasan, Sangar A.& Abd Allah, Midya Nuri. Synthesis, spectroscopic study and biological activity of some new heterocyclic compounds derived from sulfadiazine. ZANCO Journal of Pure and Applied Sciences Vol. 31, no. 6 (2019), pp.92-109.
https://search.emarefa.net/detail/BIM-949373
American Medical Association (AMA)
Hasan, Sangar A.& Abd Allah, Midya Nuri. Synthesis, spectroscopic study and biological activity of some new heterocyclic compounds derived from sulfadiazine. ZANCO Journal of Pure and Applied Sciences. 2019. Vol. 31, no. 6, pp.92-109.
https://search.emarefa.net/detail/BIM-949373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 109
Record ID
BIM-949373