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Bio-distribution of gold nanoparticles in tumor mass and different organs in implanted mice with mammary adenocarcinoma am3 : in vivo study
Other Title(s)
التوزيع الحيوي لجزيئات الذهب النانوية في الورم و الأعضاء المختلفة للفئران المغروسة بسرطان الغدد اللبنية : دراسة داخل الجسم الحي
Joint Authors
Husayn, Sumayyah Ibrahim
Shabar, Salihah Sahib Musa
Yasin, Nahi Yusuf
Source
Iraqi Journal of Veterinary Medicine
Issue
Vol. 43, Issue 2 (31 Dec. 2019), pp.17-22, 6 p.
Publisher
University of Baghdad College of Veterinary Medicine
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Abstract EN
Nanoparticles has many properties, especially in treatment of medical field, but the controversy continues about their cytotoxicity.
Hence, this research was conducted to estimate the concentration of gold nanoparticles (GNPs) in tumor and other organs such as kidney, liver, and spleen after injection GNPs by two routes, intratumor and intraperitoneal to compare between two methods in mice implanted with mammary adenocarcinoma for 28 days.
Atomic Absorption Spectroscopy was used to measure the GNPs concentrations.
The results revealed that the GNPs concentrations were significantly (P≤0.05) increased (3.75±1.75, 2.42 ±0.31 ppm) in kidney tissue after intratumor and intraperitoneal administration, respectively, when compared to the other organs (liver and spleen), followed by tumor mass (2.66±0.01, 1.09 ±0.06 ppm) in tissue.
While the concentrations of GNPs in spleen and liver were (1.40 ±0.33, 0.726 ±0.01) and (0.602 ±0.03, 0.517 ±0.02) after intratumor and intraperitoneal administration respectively.
Also, the experiment showed that the injection by intratumor was more efficient than intraperitonial method for tumor treatment, so, the nanoparticles were cleared by responsible lymphoid organs of body.
American Psychological Association (APA)
Husayn, Sumayyah Ibrahim& Shabar, Salihah Sahib Musa& Yasin, Nahi Yusuf. 2019. Bio-distribution of gold nanoparticles in tumor mass and different organs in implanted mice with mammary adenocarcinoma am3 : in vivo study. Iraqi Journal of Veterinary Medicine،Vol. 43, no. 2, pp.17-22.
https://search.emarefa.net/detail/BIM-952747
Modern Language Association (MLA)
Husayn, Sumayyah Ibrahim…[et al.]. Bio-distribution of gold nanoparticles in tumor mass and different organs in implanted mice with mammary adenocarcinoma am3 : in vivo study. Iraqi Journal of Veterinary Medicine Vol. 43, no. 2 (2019), pp.17-22.
https://search.emarefa.net/detail/BIM-952747
American Medical Association (AMA)
Husayn, Sumayyah Ibrahim& Shabar, Salihah Sahib Musa& Yasin, Nahi Yusuf. Bio-distribution of gold nanoparticles in tumor mass and different organs in implanted mice with mammary adenocarcinoma am3 : in vivo study. Iraqi Journal of Veterinary Medicine. 2019. Vol. 43, no. 2, pp.17-22.
https://search.emarefa.net/detail/BIM-952747
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 20-21
Record ID
BIM-952747