Drug reaction with eosinophilia and systemic symptoms (DRESS) presenting with primary diagnosis of hepatocellular carcinoma
Joint Authors
Hormati, Ahmad
Alimi, Faizah
Adili, Sayyid Hasan
Zojaji, Mohaddeseh
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 22, Issue 3 (31 Mar. 2020), pp.1-4, 4 p.
Publisher
Publication Date
2020-03-31
Country of Publication
United Arab Emirates
No. of Pages
4
Main Subjects
Topics
Abstract EN
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an uncommon systemic allergic reaction, which usually occurs due to a specific medication.
The most common presentation is fever, skin eruption, and lymphadenopathy that presents two to eight weeks after exposure to the culprit drug.
In some cases, evidence of internal organ involvement including renal failure, respiratory symptoms, or liver involvement may present.
These symptoms may present weeks to months after the exposure or even discontinuing the drug, which makes the diagnosis challenging.
This report presents a young man with first presentation of icter and elevated liver enzymes, whose laboratory and imaging studies failed to diagnose the disease.
A liver biopsy was performed and the pathologist reported hepatocellular carcinoma (HCC).
A high level of serum alpha-fetoprotein was consistent with the histologic findings, but concerning the uncommon clinical setting, the pathologic specimen was reviewed by another pathologist, which reported hepatocyte regeneration following hepatitis.
This finding was consistent with elevated serum alpha-fetoprotein.
A retrospective review revealed the history of using ceftriaxone nine months before the presentation and his final diagnosis was the DRESS syndrome with a dramatic response to corticosteroid treatment.
American Psychological Association (APA)
Hormati, Ahmad& Alimi, Faizah& Adili, Sayyid Hasan& Zojaji, Mohaddeseh. 2020. Drug reaction with eosinophilia and systemic symptoms (DRESS) presenting with primary diagnosis of hepatocellular carcinoma. Iranian Red Crescent Medical Journal،Vol. 22, no. 3, pp.1-4.
https://search.emarefa.net/detail/BIM-954821
Modern Language Association (MLA)
Hormati, Ahmad…[et al.]. Drug reaction with eosinophilia and systemic symptoms (DRESS) presenting with primary diagnosis of hepatocellular carcinoma. Iranian Red Crescent Medical Journal Vol. 22, no. 3 (Mar. 2020), pp.1-4.
https://search.emarefa.net/detail/BIM-954821
American Medical Association (AMA)
Hormati, Ahmad& Alimi, Faizah& Adili, Sayyid Hasan& Zojaji, Mohaddeseh. Drug reaction with eosinophilia and systemic symptoms (DRESS) presenting with primary diagnosis of hepatocellular carcinoma. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 3, pp.1-4.
https://search.emarefa.net/detail/BIM-954821
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4
Record ID
BIM-954821