Association between KRAS rs 712 G >T polymorphism with the incidence of breast tumors in iraqi women
Joint Authors
Jasim, Hamid M.
al-Haddad, Ruya H.
Salih, Wiam Abd al-Fattah
Source
Iraqi Journal of Biotechnology
Issue
Vol. 18, Issue 3 (31 Dec. 2019), pp.55-61, 7 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2019-12-31
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
Recently, Single nucleotide polymorphisms (SNPs) located in the 3'-UTR of the KRAS (KRAS rs712 (G>T)) which interrupts let-7 miRNA binding site was stated to be associated with the occurrence of many human cancers.
This study aimed to assess the association of KRAS rs712 polymorphism with the occurrence of breast cancer and breast benign tumor in Iraqi women.
rs712 in 3' UTR of the KRAS gene was amplified by using specific primers, then genotype was detected after sequencing of the amplified products.
Results of genotyping showed that mutant type TT was significantly associated in women with breast cancer versus women breast benign tumors and in women with breast benign tumors versus healthy women.
However, the results showed there is no significant association in women with breast cancer versus healthy women.
Based on the results, rs712 polymorphism in the 3' UTR of the KRAS gene was considered as a risk factor with the occurrence of breast cancer and breast benign tumor in Iraqi women compared with healthy women
American Psychological Association (APA)
al-Haddad, Ruya H.& Jasim, Hamid M.& Salih, Wiam Abd al-Fattah. 2019. Association between KRAS rs 712 G >T polymorphism with the incidence of breast tumors in iraqi women. Iraqi Journal of Biotechnology،Vol. 18, no. 3, pp.55-61.
https://search.emarefa.net/detail/BIM-955675
Modern Language Association (MLA)
Salih, Wiam Abd al-Fattah…[et al.]. Association between KRAS rs 712 G >T polymorphism with the incidence of breast tumors in iraqi women. Iraqi Journal of Biotechnology Vol. 18, no. 3 (Dec. 2019), pp.55-61.
https://search.emarefa.net/detail/BIM-955675
American Medical Association (AMA)
al-Haddad, Ruya H.& Jasim, Hamid M.& Salih, Wiam Abd al-Fattah. Association between KRAS rs 712 G >T polymorphism with the incidence of breast tumors in iraqi women. Iraqi Journal of Biotechnology. 2019. Vol. 18, no. 3, pp.55-61.
https://search.emarefa.net/detail/BIM-955675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 60-61
Record ID
BIM-955675
