Rate of microRNA-101 level in sample of Iraqi patients with chronic hepatitis B virus infection

Abstract EN

Hepatitis B virus (HBV) Infection is highly widespread.

Chronic hepatitis B infection (CHB) leads to expansion of complications, like cirrhosis, hepatocellular carcinoma (HCC) and death.

microRNAs are emerging as biomarkers for liver disease development .

this study aims to rated the level of serum miR-101 alteration in patients with CHB and inactive carrier comparing with healthy control.

A total of 67 patient’s blood samples collected during the period from February 2019 to September 2019 at Hepatology and Gastroenterology Teaching Hospital .The serum miRNA-101 expression were detected using real time PCR.

The results showed that the serum miR-101 was downregulated in the chronic HBV and inactive carrier comparing with the healthy subjects but there was no significant difference (P = 0.630) was observed among them.