Histopathological changes effects of Lactobacillus acidophilus filtrate and cyclophosphomide drug on albino male mice

Abstract EN

Probiotics are formulations containing microbial stimulants that have some beneficial influence on the maintenance of a balanced intestinal macrobiotic and on the resistance to infections.

This study was designed to evaluate the effects of lactobacillus acidophilus at the concentrations (10P5P, 10P10P cfu/ml) and the effects of cyclophoamide drug at concentration (15 mg/kg) on the histopathological of stomach, liver and spleen tissues on albino male mice.

The results showed congestion, degeneration and necrosis of spleenic, liver and stomach tissues when animals injected with cyclophosoamide, while the results of tissues which infected with lactobacillus acidophilus were showed normal shape of stomach, liver and spleenic tissues in comparison with negative and positive controls.

However, in pre and post-treatment, stomach, liver and spleen sections were showed mild histpathological change when infected with lactobacillus acidophilus in comparison with negative control.

It is concluded that lactobacillus acidophilus has not show histopathological changes on organs of mice