Immunoglobulins IgG, IgA, IgM, complement C3 and C4 levels in sera of patients with polycystic ovary syndrome and the risk of cardiovascular diseases
Other Title(s)
مستويات البروتينات المناعية IgG, IgA, IgM و المتممات C3, C4 في مصول المريضات بمتلازمة تكيس المبيض كدليل لتنبأ بخطر الإصابة بأمراض القلب الوعائية
Joint Authors
Abd al-Rahman, Shadha Abd al-Wadud
Abu al-Tamin, Nada Abd al-Karim Kazim
Husayn, Maysun Khalid
Source
Iraqi Journal of Biotechnology
Issue
Vol. 14, Issue 2 (31 Dec. 2015), pp.329-338, 10 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age.
This study was designed to explore the clinical utility of humoral components of the immune system as a predictive of cardiovascular risk in PCOS patients.
Women with PCOS (n =52) were recruited from Kamal AL-Samaraee Hospital.17 healthy, age-matched female volunteers were recruited as control subjects.
We measured serum immunoglobulin (IgG,IgA,IgM), complement(C3,C4) concentrations in both groups.
Results: Compared with controls, women with PCOS had significant increase (p<0.05) in C3(147.630±42.557vs.
54.611±14.177mg/dL),C4 (30.382± 12.549vs.15.741±4.917mg/dL),IgG (1011.811±310.347vs.746.788±210.311mg/dL),IgA(250.100±104.467vs.
140.311±6.783mg/dL), and IgM(194.700±81.976 vs.
126.023±32.103mg/dL) levels.
C3 of patients group showed positive significant correlation with C4(r=0.311,p=0.025) and IgM(r=0.276,p=0.047).
IgG positively correlated with IgA(r=0.358,p=0.009) and with testosterone(r=0.275, p=0.047), also IgM showed positive correlation with C3/C4.
Conclusion: increase circulating Immunoglobulin and complement component might serve as a signal for the presence of an immune response that may increase cardiovascular risk in PCOS patients.
American Psychological Association (APA)
Abd al-Rahman, Shadha Abd al-Wadud& Abu al-Tamin, Nada Abd al-Karim Kazim& Husayn, Maysun Khalid. 2015. Immunoglobulins IgG, IgA, IgM, complement C3 and C4 levels in sera of patients with polycystic ovary syndrome and the risk of cardiovascular diseases. Iraqi Journal of Biotechnology،Vol. 14, no. 2, pp.329-338.
https://search.emarefa.net/detail/BIM-955971
Modern Language Association (MLA)
Abd al-Rahman, Shadha Abd al-Wadud…[et al.]. Immunoglobulins IgG, IgA, IgM, complement C3 and C4 levels in sera of patients with polycystic ovary syndrome and the risk of cardiovascular diseases. Iraqi Journal of Biotechnology Vol. 14, no. 2 (2015), pp.329-338.
https://search.emarefa.net/detail/BIM-955971
American Medical Association (AMA)
Abd al-Rahman, Shadha Abd al-Wadud& Abu al-Tamin, Nada Abd al-Karim Kazim& Husayn, Maysun Khalid. Immunoglobulins IgG, IgA, IgM, complement C3 and C4 levels in sera of patients with polycystic ovary syndrome and the risk of cardiovascular diseases. Iraqi Journal of Biotechnology. 2015. Vol. 14, no. 2, pp.329-338.
https://search.emarefa.net/detail/BIM-955971
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 335-338
Record ID
BIM-955971