Thyroid dysfunction among chronic hepatitis C patients and its relation to Interferon therapy

Joint Authors

Muhammad, Marwah A.
Ahmad, Lubna A. Abd al-Wahid
al-Tuni, Lubna Faraj

Source

Journal of Current Medical Research and Practice

Issue

Vol. 5, Issue 1 (31 Mar. 2020), pp.50-56, 7 p.

Publisher

Assiut University Faculty of Medicine

Publication Date

2020-03-31

Country of Publication

Egypt

No. of Pages

7

Main Topic

Diseases

Topics

Abstract EN

Background: Thyroid dysfunction (TD) represents an extrahepatic manifestation of chronic hepatitis C (CHC).

Moreover, the currently approved treatment of CHC is often associated with TD.

However, it remains debatable if TD is mainly virus or treatment related.

The aim of this study was to assess the incidence of TD and to identify its predictors in treated and untreated CHC-infected patients.

Patients and methods: A total of 1290 patients with CHC were evaluated for TD for 48 weeks: 200 were untreated (control group) and 1090 were treated with pegylated interferon α (PEG-IFN-α) plus ribavirin (treatment group).

Results: The incidence of TD was more evident by the end of treatment (week 48); it was found to be 15.5%, mostly in the form of hypothyroidism (8.4%), whereas the least incidence was detected by week 12 (9.1%), mostly in the form of hyperthyroidism (5.2%).

Generally, hyperthyroidism was higher than hypothyroidism in multiple folds, but in the end, hypothyroid cases became more dominant.

Males were more affected, but the prevalence of hypothyroidism was more in females (10.1%) than males (8.0%).

TD was not related to sex, age, BMI, pretreatment viral load, pretreatment laboratory characteristics, post-treatment biochemical tests, treatment duration, severity of hepatic inflammation and fibrosis, type of biopsy used, or virological outcome, but PEG-IFN formulation was related, particularly IFN-α-2a.

TD did not lead to dose reduction or therapy withdrawal.

Conclusion: Both hepatitis C virus and IFN-α therapy have been found to be inducing thyroid disorders in patients with CHC virus infection.

Antiviral therapy of CHC possibly induces de novo or exacerbates pre-existing silent TD especially subclinical hypothyroidism.

The role of CHC per se in TD remains to be determined.

American Psychological Association (APA)

al-Tuni, Lubna Faraj& Muhammad, Marwah A.& Ahmad, Lubna A. Abd al-Wahid. 2020. Thyroid dysfunction among chronic hepatitis C patients and its relation to Interferon therapy. Journal of Current Medical Research and Practice،Vol. 5, no. 1, pp.50-56.
https://search.emarefa.net/detail/BIM-956257

Modern Language Association (MLA)

al-Tuni, Lubna Faraj…[et al.]. Thyroid dysfunction among chronic hepatitis C patients and its relation to Interferon therapy. Journal of Current Medical Research and Practice Vol. 5, no. 1 (Jan. / Mar. 2020), pp.50-56.
https://search.emarefa.net/detail/BIM-956257

American Medical Association (AMA)

al-Tuni, Lubna Faraj& Muhammad, Marwah A.& Ahmad, Lubna A. Abd al-Wahid. Thyroid dysfunction among chronic hepatitis C patients and its relation to Interferon therapy. Journal of Current Medical Research and Practice. 2020. Vol. 5, no. 1, pp.50-56.
https://search.emarefa.net/detail/BIM-956257

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 55-56

Record ID

BIM-956257