Analysis of native kidney biopsy : data from a single center from Bihar, India
Joint Authors
Singh, Prit Pal
Krishna, Amresh
Kumar, Om
Vardhan, Harsh
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 29, Issue 5 (31 Oct. 2018), pp.1174-1180, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2018-10-31
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
This is a retrospective study of all native kidney biopsies performed at our center between October 1, 2012 and March 31, 2015.
Relevant clinical and laboratory variables were recorded.
Biopsy samples were processed for light microscopy and immunofluorescence in all cases.
Histological classification was adapted from the World Health Organization recommen- dations.
The indications for kidney biopsy were nephrotic syndrome in adults in 190 cases, rapidly progressive renal failure in 43, unexplained renal failure in 25, and steroid-resistant nephrotic syndrome in children in 12.
The mean age of the patients was 31.48 ± 13.46 years.
Male-to-female ratio was 1.87:1.
Mean serum creatinine (SCr) of the patients was 2.36 ± 2.07 mg/dL.
Primary glomerulonephritis accounted for 88.89% of cases (240) while secondary glomerulonephritis accounted for 7.40% of total cases (20).
Interstitial disease accounted for 1.5% and vascular disease for 2.2%.
The most common lesion among primary glomerulonephritis was focal segmental glomerulosclerosis (FSGS) (31.11%) followed by diffuse proliferative glomerulonephritis (DPGN) (13.33%) and membranous glomerulonephritis (MGN) (12.59%).
Among secondary glomerulonephritis, lupus nephritis was the most common (5.56%).
In patients with SCr 1.4 mg/dL or less (n = 131), FSGS was the most common histology (17.26%) followed by MGN (23.66%) and minimal change disease (7.63%).
Whereas, in patients with SCr more than 1.4 mg/dL (n = 139), DPGN was the most common diagnosis (23.74%) followed by FSGS (17.26%) and IgAN (12.23%).
Fourteen patients (5.2%) had one or more episode of gross hematuria, three of whom required blood transfusion.
The overall FSGS was the most common lesion seen.
When we consider only patients with deranged renal function, DPGN was the most common histopathological lesion.
The reason for disproportionate high incidence for DPGN is not clear and requires further research.
American Psychological Association (APA)
Krishna, Amresh& Vardhan, Harsh& Singh, Prit Pal& Kumar, Om. 2018. Analysis of native kidney biopsy : data from a single center from Bihar, India. Saudi Journal of Kidney Diseases and Transplantation،Vol. 29, no. 5, pp.1174-1180.
https://search.emarefa.net/detail/BIM-956631
Modern Language Association (MLA)
Krishna, Amresh…[et al.]. Analysis of native kidney biopsy : data from a single center from Bihar, India. Saudi Journal of Kidney Diseases and Transplantation Vol. 29, no. 5 (Sep. / Oct. 2018), pp.1174-1180.
https://search.emarefa.net/detail/BIM-956631
American Medical Association (AMA)
Krishna, Amresh& Vardhan, Harsh& Singh, Prit Pal& Kumar, Om. Analysis of native kidney biopsy : data from a single center from Bihar, India. Saudi Journal of Kidney Diseases and Transplantation. 2018. Vol. 29, no. 5, pp.1174-1180.
https://search.emarefa.net/detail/BIM-956631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1180
Record ID
BIM-956631